(S)-methyl 2-((2S,3S)-3-methylaziridine-2-carboxamido)-3-phenylpropanoate

Base Information

Chemical Name:(S)-methyl 2-((2S,3S)-3-methylaziridine-2-carboxamido)-3-phenylpropanoate
CAS No.:1378482-75-7
Molecular Formula:C₁₄H₁₈N₂O₃
Molecular Weight:262.309
Hs Code.:

Synonyms:(S)-methyl 2-((2S,3S)-3-methylaziridine-2-carboxamido)-3-phenylpropanoate

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Chemical Property of (S)-methyl 2-((2S,3S)-3-methylaziridine-2-carboxamido)-3-phenylpropanoate

Chemical Property:

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Technology Process of (S)-methyl 2-((2S,3S)-3-methylaziridine-2-carboxamido)-3-phenylpropanoate

There total 2 articles about (S)-methyl 2-((2S,3S)-3-methylaziridine-2-carboxamido)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1378482-73-5
(S)-methyl 2-((2S,3S)-3-methyl-1-tritylaziridine-2-carboxamido)-3-phenylpropanoate

: 1378482-75-7
(S)-methyl 2-((2S,3S)-3-methylaziridine-2-carboxamido)-3-phenylpropanoate

Guidance literature:: With trifluoroacetic acid; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; chloroform; at -30 - -10 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol301178r

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 1378482-75-7
(S)-methyl 2-((2S,3S)-3-methylaziridine-2-carboxamido)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: PyBOP; N-ethyl-N,N-diisopropylamine / chloroform / 13 h / 23 °C / Inert atmosphere

2: trifluoroacetic acid / methanol; 5,5-dimethyl-1,3-cyclohexadiene; chloroform / 2 h / -30 - -10 °C / Inert atmosphere

With PyBOP; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; chloroform;
DOI:10.1021/ol301178r

Reference yield:

: 1378482-75-7
(S)-methyl 2-((2S,3S)-3-methylaziridine-2-carboxamido)-3-phenylpropanoate

: (6S,9S,12S)-methyl 9-((R)-1-azidoethyl)-12-benzyl-6-isobutyl-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate

Guidance literature:: Multi-step reaction with 2 steps

1: PyBOP; N-ethyl-N,N-diisopropylamine / chloroform / 13 h / 23 °C / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide / 24 h / 60 °C / Inert atmosphere

With sodium azide; PyBOP; N-ethyl-N,N-diisopropylamine; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ol301178r