(S)-methyl 2-((2S,3S)-3-methyl-1-tritylaziridine-2-carboxamido)-3-phenylpropanoate

Base Information

Chemical Name:(S)-methyl 2-((2S,3S)-3-methyl-1-tritylaziridine-2-carboxamido)-3-phenylpropanoate
CAS No.:1378482-73-5
Molecular Formula:C₃₃H₃₂N₂O₃
Molecular Weight:504.629
Hs Code.:

Synonyms:(S)-methyl 2-((2S,3S)-3-methyl-1-tritylaziridine-2-carboxamido)-3-phenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 2-((2S,3S)-3-methyl-1-tritylaziridine-2-carboxamido)-3-phenylpropanoate

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Technology Process of (S)-methyl 2-((2S,3S)-3-methyl-1-tritylaziridine-2-carboxamido)-3-phenylpropanoate

There total 1 articles about (S)-methyl 2-((2S,3S)-3-methyl-1-tritylaziridine-2-carboxamido)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 74481-57-5
(2S,3S)-1-trityl-3-methyl-2-aziridinecarboxylic acid

: 1378482-73-5
(S)-methyl 2-((2S,3S)-3-methyl-1-tritylaziridine-2-carboxamido)-3-phenylpropanoate

Guidance literature:: With PyBOP; N-ethyl-N,N-diisopropylamine; In chloroform; at 23 ℃; for 13h; Inert atmosphere;
DOI:10.1021/ol301178r

Reference yield:

: 1378482-73-5
(S)-methyl 2-((2S,3S)-3-methyl-1-tritylaziridine-2-carboxamido)-3-phenylpropanoate

: 1378482-75-7
(S)-methyl 2-((2S,3S)-3-methylaziridine-2-carboxamido)-3-phenylpropanoate

Guidance literature:: With trifluoroacetic acid; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; chloroform; at -30 - -10 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol301178r

Reference yield:

: 1378482-73-5
(S)-methyl 2-((2S,3S)-3-methyl-1-tritylaziridine-2-carboxamido)-3-phenylpropanoate

: 1378482-63-3
(S)-methyl 2-((2S,3S)-1-((S)-2-((tert-butoxycarbonyl)amino)-4-methylpentanoyl)-3-methylaziridine-2-carboxamido)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / methanol; 5,5-dimethyl-1,3-cyclohexadiene; chloroform / 2 h / -30 - -10 °C / Inert atmosphere

2: PyBOP; N-ethyl-N,N-diisopropylamine / chloroform / 13 h / 23 °C / Inert atmosphere

With PyBOP; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; chloroform;
DOI:10.1021/ol301178r