Ethyl 4-bromo-3-chlorobenzoate

Base Information

• Chemical Name: Ethyl 4-bromo-3-chlorobenzoate
• CAS No.: 120077-67-0
• Molecular Formula: C₉H₈BrClO₂
• Molecular Weight: 263.518
• Mol file: 120077-67-0.mol

Synonyms:4-bromo-3-chlorobenzoic acid ethyl ester

Chemical Property of Ethyl 4-bromo-3-chlorobenzoate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl4-Bromo-3-chlorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-bromo-3-chlorobenzoate

There total 3 articles about Ethyl 4-bromo-3-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethanol (64-17-5) + 4-bromo-3-chlorobenzoic acid (25118-59-6) → 4-bromo-3-chlorobenzoic acid ethyl ester (120077-67-0)

Guidance literature:

With sulfuric acid; Reflux;

Reference yield:

1-amino-2-chloro-4-carboethoxybenzene (82765-44-4) → 4-bromo-3-chlorobenzoic acid ethyl ester (120077-67-0)

Guidance literature:

With copper(I) bromide; sodium nitrite; In water; hydrogen bromide;

Reference yield:

3-chlorobenzoate (535-80-8) → 4-bromo-3-chlorobenzoic acid ethyl ester (120077-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KBrO₃ / aq. H₂SO₄; acetic acid / 1.5 h / Heating

2: cc. H₂SO₄

With potassium bromate; cc. H₂SO₄; In sulfuric acid; acetic acid;

upstream raw materials:

ethanol

4-bromo-3-chlorobenzoic acid

3-chlorobenzoate

1-amino-2-chloro-4-carboethoxybenzene

Downstream raw materials:

ethyl 3-chloro-4-cyanobenzoate

(2-chloro-4-((N-(2-(4-chlorophenyl)-5-cyclopropyl-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-6-yl)methylsulfonamido)methyl)phenyl)boronic acid

6-(N-(3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)methylsulfonamido)-2-(4-chlorophenyl)-5-cyclopropyl-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide

6-(N-(4-bromo-3-chlorobenzyl)methylsulfonamido)-2-(4-chlorophenyl)-5-cyclopropyl-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide

Refernces

• 1、 -. "SUBSTITUTED TRICYCLIC COMPOUNDS WITH ACTIVITY TOWARDS EP1 RECEPTORS". Page/Page column 96. . Retrieved 2013/10/22.
• 2、 -. "IMIDAZO [1,2A] PYRIDINE DERIVATIVES, THEIR USE AS S1P1 AGONISTS AND METHODS FOR THEIR PRODUCTION". Page/Page column 118-119. . Retrieved 2010/06/20.