tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-4-(4-methoxyphenyl)-4-oxobutanoate

Base Information

Chemical Name:tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-4-(4-methoxyphenyl)-4-oxobutanoate
CAS No.:174464-15-4
Molecular Formula:C₂₀H₂₉NO₆
Molecular Weight:379.453
Hs Code.:

Synonyms:tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-4-(4-methoxyphenyl)-4-oxobutanoate

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Chemical Property of tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-4-(4-methoxyphenyl)-4-oxobutanoate

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Technology Process of tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-4-(4-methoxyphenyl)-4-oxobutanoate

There total 5 articles about tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-4-(4-methoxyphenyl)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 5720-07-0
4-methoxyphenylboronic acid

: Boc-Asp(OPh)-O^tBu

: 174464-15-4
tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-4-(4-methoxyphenyl)-4-oxobutanoate

Guidance literature:: With [(η³-1-^tBu-indenyl)Pd(1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene)(Cl)]; potassium carbonate; In tetrahydrofuran; at 60 ℃; for 4h; Reagent/catalyst; Solvent; Catalytic behavior; Glovebox; Inert atmosphere;
DOI:10.1021/acs.orglett.9b02214

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: Boc-Asp(OPh)-O^tBu

: 34582-32-6
N-tert-butoxycarbonyl aspartic acid tert-butyl ester

: 174464-15-4
tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-4-(4-methoxyphenyl)-4-oxobutanoate

Guidance literature:: With [(η³-1-^tBu-indenyl)Pd(1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene)(Cl)]; water; potassium carbonate; In tetrahydrofuran; at 60 ℃; for 4h; Overall yield = 29 percentChromat.; Glovebox; Inert atmosphere;
DOI:10.1021/acs.orglett.9b02214

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: C₁₉H₂₇NO₆

: 174464-15-4
tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-4-(4-methoxyphenyl)-4-oxobutanoate

Guidance literature:: With [(η³-1-^tBu-indenyl)Pd(1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene)(Cl)]; potassium carbonate; In tetrahydrofuran; at 60 ℃; for 4h; Glovebox; Inert atmosphere;
DOI:10.1021/acs.orglett.9b02214