(6(S)-(((5-chloropyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone

Base Information

Chemical Name:(6(S)-(((5-chloropyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone
CAS No.:1262396-05-3
Molecular Formula:C₂₄H₂₄ClN₅O
Molecular Weight:433.94
Hs Code.:

Synonyms:(6(S)-(((5-chloropyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone

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Chemical Property of (6(S)-(((5-chloropyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone

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Technology Process of (6(S)-(((5-chloropyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone

There total 7 articles about (6(S)-(((5-chloropyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1088994-22-2
5-methyl-2-(pyrimidin-2-yl)benzoic acid

: 1262397-20-5
N-(5-azaspiro[2.4]heptan-6(S)-ylmethyl)-5-chloropyridin-2-amine

: 1262396-05-3
(6(S)-(((5-chloropyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Reflux;

Reference yield:

: 1262397-06-7
tert-butyl 4-methylene-2(S)-((4-nitrobenzoyloxy)methyl)pyrrolidine-1-carboxylate

: 1262396-05-3
(6(S)-(((5-chloropyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: palladium diacetate / tetrahydrofuran / 2 h / 20 °C

1.2: -60 - 20 °C

2.1: sodium hydroxide / water; methanol / 0 - 20 °C

3.1: TEMPO; BAIB / dichloromethane / 2 h / 25 °C

4.1: acetic acid / dichloromethane / 2 h / 20 °C

5.1: sodium tris(acetoxy)borohydride / dichloromethane; acetic acid / 18 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Reflux

With sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid;

Reference yield:

: C₁₇H₂₂ClN₃O₂

: 1262396-05-3
(6(S)-(((5-chloropyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / dichloromethane; acetic acid / 18 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Reflux

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetic acid;