4-phenoxybenzyl azide

Base Information

• Chemical Name: 4-phenoxybenzyl azide
• CAS No.: 1254305-69-5
• Molecular Formula: C₁₃H₁₁N₃O
• Molecular Weight: 225.25
• Mol file: 1254305-69-5.mol

Synonyms:4-phenoxybenzyl azide

Chemical Property of 4-phenoxybenzyl azide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-phenoxybenzyl azide

There total 3 articles about 4-phenoxybenzyl azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

(4-phenoxyphenyl)methanol (2215-78-3) → 4-phenoxybenzyl azide (1254305-69-5)

Guidance literature:

With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 26h; Inert atmosphere;

DOI:10.1002/anie.201002205

Reference yield:

1-(bromomethyl)-4-phenoxybenzene (36881-42-2) → 4-phenoxybenzyl azide (1254305-69-5)

Guidance literature:

With sodium azide; In water; N,N-dimethyl-formamide; at 85 ℃;

DOI:10.1016/j.ejmech.2014.03.062

Reference yield:

4-Phenoxybenzoic acid (2215-77-2) → 4-phenoxybenzyl azide (1254305-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 7 h / Reflux

2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 24 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm300837y

upstream raw materials:

(4-phenoxyphenyl)methanol

4-Phenoxybenzoic acid

1-(bromomethyl)-4-phenoxybenzene

Downstream raw materials:

C₂₀H₁₆N₄O₃S

C₁₆H₁₄N₄O₃

C₂₈H₂₃N₅O₂

C₂₆H₂₁N₅O₂S