(4-Phenoxyphenyl)methanol

Base Information

• Chemical Name: (4-Phenoxyphenyl)methanol
• CAS No.: 2215-78-3
• Molecular Formula: C13H12O2
• Molecular Weight: 200.237
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID40356553
• Nikkaji Number: J567.214G
• Wikidata: Q63392782
• ChEMBL ID: CHEMBL4850613
• Mol file: 2215-78-3.mol

Synonyms:(4-phenoxyphenyl)methanol;2215-78-3;4-Phenoxybenzyl alcohol;4-Phenoxybenzylalcohol;CHEMBL4850613;MFCD01463970;Benzenemethanol, 4-phenoxy-;(4-Phenoxy-phenyl)-methanol;p-phenoxybenzyl alcohol;Oprea1_064528;SCHEMBL510065;(4-(phenyloxy)phenyl)methanol;DTXSID40356553;FEOMFFKZOZMBKD-UHFFFAOYSA-N;AMY25015;BDBM50575467;AKOS009246881;AS-8685;s11105;AC-21021;CS-0142128;FT-0690453;EN300-1862150;AE-562/12222822;Q63392782;RZN

Chemical Property of (4-Phenoxyphenyl)methanol

Chemical Property:

• Vapor Pressure: 5.5E-05mmHg at 25°C
• Melting Point: 54.5-56 °C
• Refractive Index: 1.595
• Boiling Point: 333.2 °C at 760 mmHg
• PKA: 14.36±0.10(Predicted)
• Flash Point: 149.1 °C
• PSA: 29.46000
• Density: 1.151 g/cm³
• LogP: 2.97120
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 200.083729621
• Heavy Atom Count: 15
• Complexity: 167

Purity/Quality:

98%, ^*data from raw suppliers

(4-Phenoxyphenyl)methanol ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OC2=CC=C(C=C2)CO
• Uses: (4-phenoxyphenyl)methanol is a useful reactant and reagent in organic reactions and synthesis.

Technology Process of (4-Phenoxyphenyl)methanol

There total 19 articles about (4-Phenoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Phenoxybenzoic acid (2215-77-2) → (4-phenoxyphenyl)methanol (2215-78-3)

Guidance literature:

4-Phenoxybenzoic acid; With sodium hydroxide; sodium tetrahydroborate; sulfuric acid; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 4h;

With methanol; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 0.5h;

Reference yield: 99.1%

→ (4-phenoxyphenyl)methanol (2215-78-3)

Guidance literature:

Reference yield: 94.0%

para-Chlorobenzyl alcohol (873-76-7) + phenol (108-95-2,27073-41-2) → (4-phenoxyphenyl)methanol (2215-78-3)

Guidance literature:

With potassium phosphate; copper(l) iodide; N¹-benzyl-N²-(5-methyl-[1,1'-biphenyl]-2-yl)oxalamide; In dimethyl sulfoxide; at 120 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.201601035

upstream raw materials:

4-phenoxy benzaldehyde

methyl 4-phenoxybenzoate

4-Phenoxybenzoic acid

(4-hydroxyphenyl)methanol

Downstream raw materials:

1-(bromomethyl)-4-phenoxybenzene

4-phenoxybenzyl chloride

4-phenoxy benzaldehyde

3,3,3-Trifluoro-2-methyl-2-(4-phenoxy-benzyloxy)-propionic acid

Refernces

• 1、 -. "Ligand compound for copper catalyzed aryl halide coupling reaction, catalytic system and coupling reaction". Paragraph 0134-0139. . Retrieved 2021/05/29.
• 2、 -. "Preparation method of 4-phenoxybenzylalcohol". Paragraph 0015; 0016; 0018. . Retrieved 2018/03/24.