8-benzyl-4-hydroxy-2-(methylthio)-7,8-dihydropyrido[2,3-d]pyrimidin-5(6H)-one

Base Information

Chemical Name:8-benzyl-4-hydroxy-2-(methylthio)-7,8-dihydropyrido[2,3-d]pyrimidin-5(6H)-one
CAS No.:1246672-05-8
Molecular Formula:C₁₅H₁₅N₃O₂S
Molecular Weight:301.369
Hs Code.:

Synonyms:8-benzyl-4-hydroxy-2-(methylthio)-7,8-dihydropyrido[2,3-d]pyrimidin-5(6H)-one

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Chemical Property of 8-benzyl-4-hydroxy-2-(methylthio)-7,8-dihydropyrido[2,3-d]pyrimidin-5(6H)-one

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Technology Process of 8-benzyl-4-hydroxy-2-(methylthio)-7,8-dihydropyrido[2,3-d]pyrimidin-5(6H)-one

There total 4 articles about 8-benzyl-4-hydroxy-2-(methylthio)-7,8-dihydropyrido[2,3-d]pyrimidin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1246672-04-7
ethyl ester of 4-(N-benzyl-N-(3-methoxy-3-oxopropyl)amino)-6-chloro-2-methyl-thio-pyrimidine-5-carboxylic acid

: 1246672-05-8
8-benzyl-4-hydroxy-2-(methylthio)-7,8-dihydropyrido[2,3-d]pyrimidin-5(6H)-one

Guidance literature:: ethyl ester of 4-(N-benzyl-N-(3-methoxy-3-oxopropyl)amino)-6-chloro-2-methyl-thio-pyrimidine-5-carboxylic acid; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; Cooling with ice;

With hydrogenchloride; water; In tetrahydrofuran; at 75 - 80 ℃; for 24h;

With sodium hydroxide; In tetrahydrofuran; water;

Reference yield:

: 6299-25-8
4,6-Dichloro-2-(methylthio)pyrimidine

: 1246672-05-8
8-benzyl-4-hydroxy-2-(methylthio)-7,8-dihydropyrido[2,3-d]pyrimidin-5(6H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 3 h / -78 °C

1.2: 4 h / -78 °C

2.1: triethylamine / tetrahydrofuran / 20 h / Cooling with ice

3.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Cooling with ice

3.2: 24 h / 75 - 80 °C

With potassium tert-butylate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran;

Reference yield:

: 959070-42-9
4,6-dichloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester

: 1246672-05-8
8-benzyl-4-hydroxy-2-(methylthio)-7,8-dihydropyrido[2,3-d]pyrimidin-5(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 20 h / Cooling with ice

2.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Cooling with ice

2.2: 24 h / 75 - 80 °C

With potassium tert-butylate; triethylamine; In tetrahydrofuran;