6-(4-t-butoxycarbonylaminoacetoxy-2-methoxyphenyl)-5-(5-fluoro-2-methylphenoxymethyl)-2,2,4-trimethyl-1,2-dihydroquinoline

Base Information

Chemical Name:6-(4-t-butoxycarbonylaminoacetoxy-2-methoxyphenyl)-5-(5-fluoro-2-methylphenoxymethyl)-2,2,4-trimethyl-1,2-dihydroquinoline
CAS No.:1027098-86-7
Molecular Formula:C₃₄H₃₉FN₂O₆
Molecular Weight:590.692
Hs Code.:

Synonyms:6-(4-t-butoxycarbonylaminoacetoxy-2-methoxyphenyl)-5-(5-fluoro-2-methylphenoxymethyl)-2,2,4-trimethyl-1,2-dihydroquinoline

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Chemical Property of 6-(4-t-butoxycarbonylaminoacetoxy-2-methoxyphenyl)-5-(5-fluoro-2-methylphenoxymethyl)-2,2,4-trimethyl-1,2-dihydroquinoline

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Technology Process of 6-(4-t-butoxycarbonylaminoacetoxy-2-methoxyphenyl)-5-(5-fluoro-2-methylphenoxymethyl)-2,2,4-trimethyl-1,2-dihydroquinoline

There total 9 articles about 6-(4-t-butoxycarbonylaminoacetoxy-2-methoxyphenyl)-5-(5-fluoro-2-methylphenoxymethyl)-2,2,4-trimethyl-1,2-dihydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 4530-20-5
BOC-glycine

: 929526-60-3
SA₂₂₃₁₃

: 1027098-86-7
6-(4-t-butoxycarbonylaminoacetoxy-2-methoxyphenyl)-5-(5-fluoro-2-methylphenoxymethyl)-2,2,4-trimethyl-1,2-dihydroquinoline

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1026777-98-9
methyl 2',4'-dimethoxy-4-nitro-[1,1'-biphenyl]-2-carboxylate

: 1027098-86-7
6-(4-t-butoxycarbonylaminoacetoxy-2-methoxyphenyl)-5-(5-fluoro-2-methylphenoxymethyl)-2,2,4-trimethyl-1,2-dihydroquinoline

Guidance literature:: Multi-step reaction with 9 steps

1.1: boron tribromide / dichloromethane / 1 h / -78 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide; methanol / 20 °C / 2206.72 Torr

3.1: iodine / 1-methyl-pyrrolidin-2-one / 72 h / 110 °C / Sealed tube

4.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

5.2: 0 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C

7.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / benzene / 1 h / 20 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane / 20 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; tributylphosphine; hydrogen; iodine; boron tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; 1,1'-azodicarbonyl-dipiperidine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;

Reference yield:

: 1026777-99-0
3-hydroxy-8-nitro-6H-dibenzo[b,d]pyran-6-one

: 1027098-86-7
6-(4-t-butoxycarbonylaminoacetoxy-2-methoxyphenyl)-5-(5-fluoro-2-methylphenoxymethyl)-2,2,4-trimethyl-1,2-dihydroquinoline

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide; methanol / 20 °C / 2206.72 Torr

2.1: iodine / 1-methyl-pyrrolidin-2-one / 72 h / 110 °C / Sealed tube

3.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

4.2: 0 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C

6.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / benzene / 1 h / 20 °C / Inert atmosphere

7.1: hydrogenchloride / 1,4-dioxane / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; tributylphosphine; hydrogen; iodine; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; 1,1'-azodicarbonyl-dipiperidine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide; benzene;