N-(1-(4-bromophenyl)cyclobutyl)-4-(difluoromethoxy)benzenesulfonamide

Base Information

Chemical Name:N-(1-(4-bromophenyl)cyclobutyl)-4-(difluoromethoxy)benzenesulfonamide
CAS No.:1331730-51-8
Molecular Formula:C₁₇H₁₆BrF₂NO₃S
Molecular Weight:432.286
Hs Code.:

Synonyms:N-(1-(4-bromophenyl)cyclobutyl)-4-(difluoromethoxy)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(1-(4-bromophenyl)cyclobutyl)-4-(difluoromethoxy)benzenesulfonamide

Chemical Property:

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Technology Process of N-(1-(4-bromophenyl)cyclobutyl)-4-(difluoromethoxy)benzenesulfonamide

There total 1 articles about N-(1-(4-bromophenyl)cyclobutyl)-4-(difluoromethoxy)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 351003-34-4
4-[(difluoromethyl)oxy]benzenesulfonyl chloride

: 1193389-40-0
1-(4-bromophenyl)cyclobutane-1-amine hydrochloride

: 1331730-51-8
N-(1-(4-bromophenyl)cyclobutyl)-4-(difluoromethoxy)benzenesulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1331730-51-8
N-(1-(4-bromophenyl)cyclobutyl)-4-(difluoromethoxy)benzenesulfonamide

: 96-32-2
bromoacetic acid methyl ester

: 1331730-52-9
methyl 2-(N-(1-(4-bromophenyl)cyclobutyl)-4-(difluoromethoxy)phenylsulfonamido)acetate

Guidance literature:: With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; at 80 ℃;

Reference yield:

: 1331730-51-8
N-(1-(4-bromophenyl)cyclobutyl)-4-(difluoromethoxy)benzenesulfonamide

: 1331730-04-1
2-(4-(difluoromethoxy)-N-(1-(4-(pyrimidin-5-yl)phenyl)cyclobutyl)phenylsulfonamido) acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine / 80 °C

2: sodium hydroxide / tetrahydrofuran; methanol / 0.33 h / 90 °C

3: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / butan-1-ol / 3 h / 100 °C / Inert atmosphere

With potassium phosphate; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; methanol; butan-1-ol; 3: Suuzzuki Coupling;