1-(4-BROMOPHENYL)CYCLOBUTANAMINE (HYDROCHLORIDE)

Base Information

• Chemical Name: 1-(4-BROMOPHENYL)CYCLOBUTANAMINE (HYDROCHLORIDE)
• CAS No.: 1193389-40-0
• Molecular Formula: C10H12BrN.ClH
• Molecular Weight: 262.577
• Hs Code.: 2921499090
• Mol file: 1193389-40-0.mol

Synonyms:1-(4-BROMOPHENYL)CYCLOBUTANAMINE (HYDROCHLORIDE);1-(4-broMophenyl)cyclobutan-1-aMine hydrochloride

Chemical Property of 1-(4-BROMOPHENYL)CYCLOBUTANAMINE (HYDROCHLORIDE)

Chemical Property:

• PSA: 26.02000
• LogP: 4.28930
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Bromophenyl)cyclobutanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-BROMOPHENYL)CYCLOBUTANAMINE (HYDROCHLORIDE)

There total 2 articles about 1-(4-BROMOPHENYL)CYCLOBUTANAMINE (HYDROCHLORIDE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.6%

1-(4-bromophenyl)cyclobutanecarboxylic acid amide (1032350-05-2) → 1-(4-bromophenyl)cyclobutane-1-amine hydrochloride (1193389-40-0)

Guidance literature:

1-(4-bromophenyl)cyclobutanecarboxylic acid amide; With sodium hypochlorite; sodium hydroxide; In water; butan-1-ol; at 20 ℃; for 18h;

With hydrogenchloride; In 1,4-dioxane; ethyl acetate;

Reference yield: 21.9%

→ 1-(4-bromophenyl)cyclobutane-1-amine hydrochloride (1193389-40-0)

Guidance literature:

With diphenylphosphoranyl azide; triethylamine; In tert-butyl alcohol; at 20 - 80 ℃; for 13h;

With hydrogenchloride; In water; at 80 ℃; for 12h;

Reference yield: 49.1%

ethyl 2-chloropyrimidine-5-carboxylate (89793-12-4) + 1-(4-bromophenyl)cyclobutane-1-amine hydrochloride (1193389-40-0) → ethyl 2-((1-(4-bromophenyl)cyclobutyl)amino)pyrimidine-5-carboxylate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 110 ℃; for 17h;

upstream raw materials:

1-(4-bromophenyl)cyclobutanecarboxylic acid amide

Downstream raw materials:

N-(1-(4-bromophenyl)cyclobutyl)-4-(difluoromethoxy)benzenesulfonamide

methyl 2-(N-(1-(4-bromophenyl)cyclobutyl)-4-(difluoromethoxy)phenylsulfonamido)acetate

2-(N-(1-(4-bromophenyl)cyclobutyl)-4-(difluoromethoxy)phenylsulfonamido)acetic acid

2-(4-(difluoromethoxy)-N-(1-(4-(pyrimidin-5-yl)phenyl)cyclobutyl)phenylsulfonamido) acetic acid