1-chloro-8-fluoro-6-(3-fluoro-4-methoxyphenyl)-2-naphthol

Base Information

Chemical Name:1-chloro-8-fluoro-6-(3-fluoro-4-methoxyphenyl)-2-naphthol
CAS No.:550998-43-1
Molecular Formula:C₁₇H₁₁ClF₂O₂
Molecular Weight:320.723
Hs Code.:

Synonyms:1-chloro-8-fluoro-6-(3-fluoro-4-methoxyphenyl)-2-naphthol

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Chemical Property of 1-chloro-8-fluoro-6-(3-fluoro-4-methoxyphenyl)-2-naphthol

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Technology Process of 1-chloro-8-fluoro-6-(3-fluoro-4-methoxyphenyl)-2-naphthol

There total 9 articles about 1-chloro-8-fluoro-6-(3-fluoro-4-methoxyphenyl)-2-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 550998-33-9
8-fluoro-6-(3-fluoro-4-methoxyphenyl)-2-naphthol

: 550998-43-1
1-chloro-8-fluoro-6-(3-fluoro-4-methoxyphenyl)-2-naphthol

Guidance literature:: With N-chloro-succinimide; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm058173s

Reference yield:

: 550998-28-2
1,6-dibromo-8-fluoro-2-naphthol

: 550998-43-1
1-chloro-8-fluoro-6-(3-fluoro-4-methoxyphenyl)-2-naphthol

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / SnCl₂; aq. HCl; acetic acid / 1 h / 100 °C

2: 85 percent / aq. Na₂CO₃; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C

3: 62 percent / NCS / tetrahydrofuran / 20 °C

With hydrogenchloride; N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; acetic acid; tin(ll) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; 2: Suzuki coupling;
DOI:10.1021/jm058173s

Reference yield:

: 13791-03-2
1-fluoro-7-methoxynaphthalene

: 550998-43-1
1-chloro-8-fluoro-6-(3-fluoro-4-methoxyphenyl)-2-naphthol

Guidance literature:: Multi-step reaction with 5 steps

1: 3.99 g / BBr₃ / CH₂Cl₂ / 0 - 20 °C

2: 62 percent / Br₂; acetic acid / 1 h / 100 °C

3: 41 percent / SnCl₂; aq. HCl; acetic acid / 1 h / 100 °C

4: 85 percent / aq. Na₂CO₃; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C

5: 62 percent / NCS / tetrahydrofuran / 20 °C

With hydrogenchloride; N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; boron tribromide; sodium carbonate; acetic acid; tin(ll) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 4: Suzuki coupling;
DOI:10.1021/jm058173s