4-benzyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)phthalazin-1(2H)-one

Base Information

Chemical Name:4-benzyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)phthalazin-1(2H)-one
CAS No.:1339174-44-5
Molecular Formula:C₂₂H₁₆N₄O
Molecular Weight:352.395
Hs Code.:

Synonyms:4-benzyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)phthalazin-1(2H)-one

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Chemical Property of 4-benzyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)phthalazin-1(2H)-one

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Technology Process of 4-benzyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)phthalazin-1(2H)-one

There total 9 articles about 4-benzyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)phthalazin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₂₀N₄O₃S

: 1339174-44-5
4-benzyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)phthalazin-1(2H)-one

Guidance literature:: With ethanol; sodium hydroxide; at 90 ℃; for 1h;

Reference yield:

: 74420-15-8
3-bromo-1H-pyrrolo[2,3-b]pyridine

: 1339174-44-5
4-benzyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)phthalazin-1(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation

3.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; ethanol; water / 0.33 h / 150 °C / Microwave irradiation

4.1: sodium hydroxide; ethanol / 1 h / 90 °C

With ethanol; potassium acetate; sodium hydride; potassium carbonate; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 64169-34-2
5-bromophthalide

: 1339174-44-5
4-benzyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)phthalazin-1(2H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 24 h / Reflux

2.1: potassium hydroxide / water / 1 h / Reflux

3.1: sodium methylate / methanol / 0.17 h / 0 °C

3.2: 1 h / 0 - 20 °C

3.3: Cooling with ice

4.1: triethylamine / tetrahydrofuran / 20 °C

5.1: hydrazine / ethanol / 2 h / Reflux

6.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; ethanol; water / 0.33 h / 150 °C / Microwave irradiation

7.1: sodium hydroxide; ethanol / 1 h / 90 °C

With N-Bromosuccinimide; ethanol; sodium methylate; potassium carbonate; triethylamine; potassium hydroxide; sodium hydroxide; hydrazine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; 1,2-dimethoxyethane; ethanol; water;