rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-3-bromo-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide trifluorocetate salt

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Chemical Name:rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-3-bromo-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide trifluorocetate salt
CAS No.:1397683-12-3
Molecular Formula:C₂HF₃O₂*C₂₀H₁₆BrN₇O
Molecular Weight:564.321
Hs Code.:

Synonyms:rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-3-bromo-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide trifluorocetate salt

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Chemical Property of rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-3-bromo-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide trifluorocetate salt

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Technology Process of rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-3-bromo-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide trifluorocetate salt

There total 2 articles about rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-3-bromo-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide trifluorocetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1397683-44-1
6-(3-aminophenyl)-6-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-amine

: 53234-55-2
5-cyano-pyridine-2-carboxylic acid

: 76-05-1
trifluoroacetic acid

: 1397683-12-3
rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-3-bromo-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide trifluorocetate salt

Guidance literature:: 5-cyano-pyridine-2-carboxylic acid; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; at 20 ℃; for 0.0833333h;

6-(3-aminophenyl)-6-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-amine; In methanol; at 0 - 20 ℃; for 4h;

trifluoroacetic acid;

Reference yield:

: 1397683-43-0
3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-thione

: 1397683-12-3
rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-3-bromo-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide trifluorocetate salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonia; methanol / water / 4 h / 60 °C / Sealed tube

1.2: 24 h / 90 °C

1.3: 1 h / 20 °C

2.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.08 h / 20 °C

2.2: 4 h / 0 - 20 °C

With methanol; ammonia; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; water;