tert-butyl 4-(5-(4-amino-2-fluorophenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(5-(4-amino-2-fluorophenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate
CAS No.:1206800-56-7
Molecular Formula:C₂₂H₂₂FN₅O₃
Molecular Weight:423.447
Hs Code.:

Synonyms:tert-butyl 4-(5-(4-amino-2-fluorophenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate

Suppliers and Price of tert-butyl 4-(5-(4-amino-2-fluorophenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 4-(5-(4-amino-2-fluorophenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of tert-butyl 4-(5-(4-amino-2-fluorophenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate

There total 21 articles about tert-butyl 4-(5-(4-amino-2-fluorophenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1206800-42-1
tert-butyl 4-(5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate

: 1206800-56-7
tert-butyl 4-(5-(4-amino-2-fluorophenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate

Guidance literature:: With hydrogen; 5% palladium over charcoal; palladium 10% on activated carbon; In tetrahydrofuran; at 20 - 35 ℃;

Reference yield:

: 1206800-24-9
6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazole

: 1206800-56-7
tert-butyl 4-(5-(4-amino-2-fluorophenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate monohydrate; di-tert-butyl dicarbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; tetrahydrofuran / 20 h / 20 - 40 °C / Large scale

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 45 h / 2585.81 Torr / Large scale

With potassium phosphate monohydrate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); di-tert-butyl dicarbonate; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; water; 1: |Suzuki Coupling;
DOI:10.1021/op400317z

Reference yield:

: 1206800-17-0
6-bromo-5-methoxy-1H-indazole

: 1206800-56-7
tert-butyl 4-(5-(4-amino-2-fluorophenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 20 - 25 °C / Large scale

2.1: aluminum (III) chloride / toluene / 5 h / 110 °C / Large scale

2.2: Large scale

3.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 15 h / 60 - 65 °C / Large scale

4.1: potassium phosphate monohydrate; di-tert-butyl dicarbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; tetrahydrofuran / 20 h / 20 - 40 °C / Large scale

5.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 45 h / 2585.81 Torr / Large scale

With aluminum (III) chloride; potassium phosphate monohydrate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); di-tert-butyl dicarbonate; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium hydrogencarbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; 4.1: |Suzuki Coupling;
DOI:10.1021/op400317z