1206800-17-0

Basic information

• Product Name: 6-Bromo-5-methoxy-1H-indazole
• Synonyms: 6-Bromo-5-methoxy-1H-indazole;1H-Indazole, 6-broMo-5-Methoxy-;6-BroMo-5-Methoxy-1H-inda...
• CAS NO: 1206800-17-0
• Molecular Formula: C₈H₇BrN₂O
• Molecular Weight: 227.05798
• Mol File: 1206800-17-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 203-208°C
• Boiling Point: 363.4±22.0 °C(Predicted)
• Appearance: /
• Density: 1.678
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.39±0.40(Predicted)
• CAS DataBase Reference: 6-Bromo-5-methoxy-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-5-methoxy-1H-indazole(1206800-17-0)
• EPA Substance Registry System: 6-Bromo-5-methoxy-1H-indazole(1206800-17-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 1206800-17-0(Hazardous Substances Data)

Usage

General Description

6-Bromo-5-methoxy-1H-indazole is a chemical compound with the molecular formula C9H8BrN2O, and it belongs to the class of indazole derivatives. It is characterized by a bromine atom and a methoxy group attached to a 5-membered ring structure containing nitrogen and oxygen atoms. 6-Bromo-5-methoxy-1H-indazole has potential applications in medicinal chemistry, as it exhibits interesting biological activities and may be used as a starting material in the synthesis of other pharmaceutical compounds. Its unique structure and properties make it a valuable chemical building block for the development of new drugs and research in the field of organic chemistry.

Upstream product

• 861076-28-0 1-bromo-2-methoxy-4-methyl-5-nitrobenzene 
• 861084-04-0 5-bromo-4-methoxy-2-methylbenzenamine 
• 31601-41-9 N-(4-methoxy-2-methylphenyl)acetamide 
• 102-50-1 2-methyl-4-methoxyaniline 

Downstream Products

• 1206799-15-6 N-(3-fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1206800-19-2 6-bromo-5-(2-fluoro-4-nitrophenoxy)-1H-indazole 
• 1206801-13-9 6-bromo-5-(2-fluoro-4-nitrophenoxy)-2-methyl-2H-indazole 
• 1206800-42-1 tert-butyl 4-(5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate 
• 1206800-56-7 tert-butyl 4-(5-(4-amino-2-fluorophenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate 
• 1206801-36-6 tert-butyl 4-(5-(2-fluoro-4-(1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate 
• 1206800-24-9 6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazole 
• 1403767-19-0 6-bromo-1-methyl-1H-indazol-5-ol 
• 1206800-67-0 3-fluoro-4-(1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yloxy)aniline 
• 1577180-07-4 N-(4-((6-bromo-1-methyl-1H-indazol-5-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1206800-27-2 6-bromo-2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-5-ol 
• 1206800-43-2 5-(2-Fluoro-4-nitrophenoxy)-1-methyl-6-(1 H-pyrazol-4-yl)-1H-indazole 
• 1206800-28-3 6-bromo-5-(2-fluoro-4-nitrophenoxy)-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole 
• 1463054-00-3 5-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole 

Relevant articles and documents

Discovery of 4-Aminoquinoline-3-carboxamide derivatives as potent reversible Bruton's tyrosine kinase inhibitors for the treatment of rheumatoid arthritis

A structure-hopping strategy was applied to discover a series of novel 4-aminoquinoline-3-carboxamide derivatives as potent, reversible BTK inhibitors. Compared to the previously described cinnoline scaffold compounds, the 4-aminoquinoline analogues showed significantly improved drug-like properties, especially in their aqueous solubility. The most potent compound, 25, displayed a stronger inhibitory effect on both BTKWT (IC50 = 5.3 nM) and BTKC481S (IC50 = 39 nM). In a rodent collagen-induced arthritis model, compound 25 efficiently reduced paw swelling without a loss in body weight. On the basis of potency, drug-like properties, stability, and noncovalent mode of inhibition, our representative inhibitors could have a promising profile to be treatments for a wide range of autoimmune diseases.

AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET

The present invention provides amidophenoxyindazole compounds useful in the treatment of cancer.