[2-{3-[(3-chloro-5-fluoro-phenyl)-((S)-2-methoxycarbonylamino-ethoxy)-methyl]-benzoylamino}-1-((R)-tetrahydro-pyran-3-ylmethyl)-ethyl]-methyl-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [2-{3-[(3-chloro-5-fluoro-phenyl)-((S)-2-methoxycarbonylamino-ethoxy)-methyl]-benzoylamino}-1-((R)-tetrahydro-pyran-3-ylmethyl)-ethyl]-methyl-carbamic acid tert-butyl ester
• CAS No.: 1093865-63-4
• Molecular Formula: C₃₂H₄₃ClFN₃O₇
• Molecular Weight: 636.161
• Mol file: 1093865-63-4.mol

Synonyms:[2-{3-[(3-chloro-5-fluoro-phenyl)-((S)-2-methoxycarbonylamino-ethoxy)-methyl]-benzoylamino}-1-((R)-tetrahydro-pyran-3-ylmethyl)-ethyl]-methyl-carbamic acid tert-butyl ester

Chemical Property of [2-{3-[(3-chloro-5-fluoro-phenyl)-((S)-2-methoxycarbonylamino-ethoxy)-methyl]-benzoylamino}-1-((R)-tetrahydro-pyran-3-ylmethyl)-ethyl]-methyl-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-{3-[(3-chloro-5-fluoro-phenyl)-((S)-2-methoxycarbonylamino-ethoxy)-methyl]-benzoylamino}-1-((R)-tetrahydro-pyran-3-ylmethyl)-ethyl]-methyl-carbamic acid tert-butyl ester

There total 33 articles about [2-{3-[(3-chloro-5-fluoro-phenyl)-((S)-2-methoxycarbonylamino-ethoxy)-methyl]-benzoylamino}-1-((R)-tetrahydro-pyran-3-ylmethyl)-ethyl]-methyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

tert-butyl (S)-1-amino-3-((R)-tetrahydro-2H-pyran-3-yl)propan-2-yl(methyl)carbamate (942145-27-9) + 3-((3-chloro-5-fluorophenyl)(2-(methoxycarbonylamino)ethoxy)methyl)benzoic acid (1093865-62-3) → [2-{3-[(3-chloro-5-fluoro-phenyl)-((S)-2-methoxycarbonylamino-ethoxy)-methyl]-benzoylamino}-1-((R)-tetrahydro-pyran-3-ylmethyl)-ethyl]-methyl-carbamic acid tert-butyl ester (1093865-63-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

(R)-2-(tetrahydro-2H-pyran-3-yl)-acetaldehyde (1013937-81-9) → [2-{3-[(3-chloro-5-fluoro-phenyl)-((S)-2-methoxycarbonylamino-ethoxy)-methyl]-benzoylamino}-1-((R)-tetrahydro-pyran-3-ylmethyl)-ethyl]-methyl-carbamic acid tert-butyl ester (1093865-63-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 1 h / 20 °C / Molecular sieve

2.1: 3-{(E)-[((1R,2R)-2-{[({(1S)-1-[(dimethylamino)carbonyl]-2,2-dimethylpropyl}amino)carbonothioyl]amino}cyclohexyl)imino]methyl}-5-(1,1-dimethylethyl)-4-hydroxyphenyl 2,2-dimethylpropanoate / toluene / 0.25 h / -78 °C

2.2: 4.17 h / -78 - 20 °C

3.1: ammonia; hydrogen / nickel / methanol / 0.5 h / 14 - 25 °C / 22801.5 Torr

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-{(E)-[((1R,2R)-2-{[({(1S)-1-[(dimethylamino)carbonyl]-2,2-dimethylpropyl}amino)carbonothioyl]amino}cyclohexyl)imino]methyl}-5-(1,1-dimethylethyl)-4-hydroxyphenyl 2,2-dimethylpropanoate; nickel; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

N-(2-((R)-tetrahydro-2H-pyran-3-yl)-eth-(E)-ylidene)methanamine (1013937-83-1) → [2-{3-[(3-chloro-5-fluoro-phenyl)-((S)-2-methoxycarbonylamino-ethoxy)-methyl]-benzoylamino}-1-((R)-tetrahydro-pyran-3-ylmethyl)-ethyl]-methyl-carbamic acid tert-butyl ester (1093865-63-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 3-{(E)-[((1R,2R)-2-{[({(1S)-1-[(dimethylamino)carbonyl]-2,2-dimethylpropyl}amino)carbonothioyl]amino}cyclohexyl)imino]methyl}-5-(1,1-dimethylethyl)-4-hydroxyphenyl 2,2-dimethylpropanoate / toluene / 0.25 h / -78 °C

1.2: 4.17 h / -78 - 20 °C

2.1: ammonia; hydrogen / nickel / methanol / 0.5 h / 14 - 25 °C / 22801.5 Torr

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-{(E)-[((1R,2R)-2-{[({(1S)-1-[(dimethylamino)carbonyl]-2,2-dimethylpropyl}amino)carbonothioyl]amino}cyclohexyl)imino]methyl}-5-(1,1-dimethylethyl)-4-hydroxyphenyl 2,2-dimethylpropanoate; nickel; In methanol; N,N-dimethyl-formamide; toluene;

upstream raw materials:

tert-butyl (S)-1-amino-3-((R)-tetrahydro-2H-pyran-3-yl)propan-2-yl(methyl)carbamate

3-((3-chloro-5-fluorophenyl)(2-(methoxycarbonylamino)ethoxy)methyl)benzoic acid

5-Chlorovaleroyl chloride

(R)-2-(tetrahydro-2H-pyran-3-yl)-acetaldehyde

Downstream raw materials:

methyl 2-((S)-(3-chloro-5-fluorophenyl)(3-((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propylcarbamoyl)phenyl)methoxy)ethylcarbamate

methyl 2-((R)-(3-chloro-5-fluorophenyl)(3-((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propylcarbamoyl)phenyl)methoxy)ethylcarbamate