1-dicyclohexylphosphino-2,3-difluorobenzenetricarbonylchromium

Base Information

• Chemical Name: 1-dicyclohexylphosphino-2,3-difluorobenzenetricarbonylchromium
• CAS No.: 1089204-99-8
• Molecular Formula: C₂₁H₂₅CrF₂O₃P
• Molecular Weight: 446.394
• Mol file: 1089204-99-8.mol

Synonyms:1-dicyclohexylphosphino-2,3-difluorobenzenetricarbonylchromium

Chemical Property of 1-dicyclohexylphosphino-2,3-difluorobenzenetricarbonylchromium

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-dicyclohexylphosphino-2,3-difluorobenzenetricarbonylchromium

There total 1 articles about 1-dicyclohexylphosphino-2,3-difluorobenzenetricarbonylchromium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

ortho-difluorobenzenetricarbonylchromium (118073-81-7) + chlorodicyclohexylphosphane (16523-54-9) → 1-dicyclohexylphosphino-2,3-difluorobenzenetricarbonylchromium (1089204-99-8)

Guidance literature:

With n-BuLi; In diethyl ether; hexane; under N2; soln. of n-BuLi in n-hexane (-78°C) added to soln. of Cr complex in Et2O; stirred for 0.5 h; phosphine added at -78°C; stirred at -78°C for 3 h; quenched with 1 M aq. HCl; extd. with EtOAc; combined extracts washed with satd. NaHCO3 and brine; org. layer dried (Na2SO4); concd. under reduced pressure; chromd. (silica gel, n-hexane-EtOAc 10:1);

DOI:10.1016/j.jorganchem.2008.08.030

Reference yield: 88.0%

1-dicyclohexylphosphino-2,3-difluorobenzenetricarbonylchromium (1089204-99-8) + water-d2 (7789-20-0) → 1-dicyclohexylphosphino-4-deuterio-2,3-difluorobenzenetricarbonylchromium (1089205-00-4)

Guidance literature:

With n-BuLi; In diethyl ether; hexane; water-d2; under N2; soln. of n-BuLi in n-hexane (-78°C) added to soln. of Cr complex in Et2O; stirred for 0.5 h; quenched with D2O; extd. with EtOAc; combined extracts washed with brine; org. layer dried (Na2SO4); concd. under reduced pressure; chromd. (silica gel, n-hexane-EtOAc 10:1);

DOI:10.1016/j.jorganchem.2008.08.030

upstream raw materials:

ortho-difluorobenzenetricarbonylchromium

chlorodicyclohexylphosphane

Downstream raw materials:

1-dicyclohexylphosphino-4-deuterio-2,3-difluorobenzenetricarbonylchromium