3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-(N-methylpiperazino)acetyl-2,4(1H,3H)-quinazolinedione

Base Information

Chemical Name:3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-(N-methylpiperazino)acetyl-2,4(1H,3H)-quinazolinedione
CAS No.:81087-68-5
Molecular Formula:C₂₆H₂₉ClN₄O₅
Molecular Weight:512.993
Hs Code.:

Synonyms:3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-(N-methylpiperazino)acetyl-2,4(1H,3H)-quinazolinedione

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Chemical Property of 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-(N-methylpiperazino)acetyl-2,4(1H,3H)-quinazolinedione

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Technology Process of 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-(N-methylpiperazino)acetyl-2,4(1H,3H)-quinazolinedione

There total 8 articles about 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-(N-methylpiperazino)acetyl-2,4(1H,3H)-quinazolinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.5%

: 109-01-3
1-methyl-piperazine

: 1-carboxy-3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione

: 81087-68-5
3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-(N-methylpiperazino)acetyl-2,4(1H,3H)-quinazolinedione

Guidance literature:: With thionyl chloride; In benzene;

Reference yield: 69.0%

: 109-01-3
1-methyl-piperazine

: 1-Chlorocarbonylmethyl-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester

: 81087-68-5
3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-(N-methylpiperazino)acetyl-2,4(1H,3H)-quinazolinedione

Guidance literature:: In benzene; for 3h; Ambient temperature;
DOI:10.1248/cpb.39.1753

Reference yield:

: 3320-83-0
o-chlorophenyl isocyanate

: 81087-68-5
3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-(N-methylpiperazino)acetyl-2,4(1H,3H)-quinazolinedione

Guidance literature:: Multi-step reaction with 6 steps

1: diethyl ether / 14 h / Ambient temperature

2: conc. HCl / ethanol / 2 h / Heating

3: 96 percent / NaH / dimethylformamide / 1 h / 80 °C

4: 70 percent / conc. HCl / 20 h / 40 °C

5: SOCl₂ / 0.5 h / Heating

6: 69 percent / benzene / 3 h / Ambient temperature

With hydrogenchloride; thionyl chloride; sodium hydride; In diethyl ether; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.39.1753