(Z)-N-(1-(4-chlorophenyl)prop-1-enyl)acetamide

Base Information

• Chemical Name: (Z)-N-(1-(4-chlorophenyl)prop-1-enyl)acetamide
• CAS No.: 220475-72-9
• Molecular Formula: C₁₁H₁₂ClNO
• Molecular Weight: 209.675
• Mol file: 220475-72-9.mol

Synonyms:(Z)-N-(1-(4-chlorophenyl)prop-1-enyl)acetamide

Chemical Property of (Z)-N-(1-(4-chlorophenyl)prop-1-enyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (Z)-N-(1-(4-chlorophenyl)prop-1-enyl)acetamide

There total 1 articles about (Z)-N-(1-(4-chlorophenyl)prop-1-enyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-chlorophenyl)-N-hydroxypropan-1-imine (56962-09-5) + acetic anhydride (108-24-7) → (Z)-N-(1-(4-chlorophenyl)prop-1-enyl)acetamide (220475-72-9)

Guidance literature:

With iron; acetic acid; In toluene; at 70 ℃; for 4h;

DOI:10.1021/ol100540p

Reference yield: 90.0%

(Z)-N-(1-(4-chlorophenyl)prop-1-enyl)acetamide (220475-72-9) + dibenzyl azodicarboxylate (2449-05-0) → C27H26ClN3O5 (1225220-24-5)

Guidance literature:

dibenzyl azodicarboxylate; With C₄₃H₆₄N₄O₄; copper(II) bis(trifluoromethanesulfonate); In tetrahydrofuran; at 30 ℃; for 1h;

(Z)-N-(1-(4-chlorophenyl)prop-1-enyl)acetamide; In tetrahydrofuran; water; at 0 ℃; enantioselective reaction; Molecular sieve;

DOI:10.1021/ol100540p

Reference yield:

(Z)-N-(1-(4-chlorophenyl)prop-1-enyl)acetamide (220475-72-9) + dibenzyl azodicarboxylate (2449-05-0) → (+)-dibenzyl 1-(1-(4-chlorophenyl)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:

dibenzyl azodicarboxylate; With C₄₃H₆₄N₄O₄; copper(II) bis(trifluoromethanesulfonate); In tetrahydrofuran; at 30 ℃; for 1h;

(Z)-N-(1-(4-chlorophenyl)prop-1-enyl)acetamide; In tetrahydrofuran; water; at 0 ℃; Molecular sieve;

With potassium hydrogensulfate; water; In tetrahydrofuran; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol100540p

upstream raw materials:

1-(4-chlorophenyl)-N-hydroxypropan-1-imine

acetic anhydride

Downstream raw materials:

C₂₇H₂₆ClN₃O₅