56962-09-5

Upstream product

• 108-90-7 chlorobenzene 
• 6285-05-8 4'-chloropropiophenone 

Downstream Products

• 74788-46-8 1-(4-chlorophenyl)propan-1-amine 
• 6285-05-8 4'-chloropropiophenone 
• 1462327-99-6 dimethyl 5-(4-chlorophenyl)-4-methyl-1H-pyrrole-2,3-dicarboxylate 
• 1462328-07-9 4-chloropropiophenone O-acetyloxime 
• 58110-86-4 2-(4'-chlorophenyl)-3-methylbenzofuran 
• 23184-97-6 2-amino-1-(4-chlorophenyl)-1-propanone hydrochloride 
• 1285694-95-2 2,6-bis(4-chlorophenyl)-3,5-dimethylpyridine 
• 1522130-53-5 C₁₈H₁₅Cl₂N 
• 220475-72-9 (Z)-N-(1-(4-chlorophenyl)prop-1-enyl)acetamide 
• 939983-55-8 erythro-3,4-bis-(4-chlorophenyl)hexane-3,4-diamine 
• 921936-96-1 C₂₁H₁₉ClNOP 

Relevant academic research and scientific papers

Synthesis method of propanil

The invention discloses a synthesis method of propanil. The synthesis method comprises the following steps: firstly performing an acylation reaction on chlorobenzene as a raw material and propionyl chloride to produce p-chloropropiophenone, then performing a condensation reaction on the p-chloropropiophenone and hydroxylamine hydrochloride to produce 1-(4-chlorophenyl)-1-acetoxime, then rearranging the 1-(4-chlorophenyl)-1-acetoxime under an acidic condition, and finally chlorinating to obtain the propanil. By the synthesis method, the reaction selectivity in each step is relatively high, no obvious side reaction occurs and the reaction conversion rate is high, so that the reaction yield is high and the product purity is high; a reaction condition is mild; the raw material cost is low; a requirement on reaction equipment is low; phosphorus-containing wastewater discharge is avoided; extension and tolerance are strong; the conversion success rate from trial production to large-scale production is high, and even if the reaction is interrupted, the trial production can be continued in the later stage; and therefore, the synthesis method is suitable for industrial mass production.

Elemental tellurium mediated synthesis of 2-(trifluoromethyl)oxazoles using trifluoroacetic anhydride as reagent

An elemental tellurium mediated synthesis of 2-(trifluoromethyl)oxazoles from the reaction of acetophenone oxime acetates with trifluoroacetic anhydride has been developed. This new tandem cyclization proceeds in good to excellent yields via a SET reduction followed by a 5-endo-trig pathway. Some of the title compounds showed fungicidal and insecticidal activities.

Preparation method of efficient and low-toxicity acaricide hexythiazox

The invention discloses a preparation method of efficient and low-toxicity acaricide hexythiazox. Performing cyclization reaction on 2-amino-1-(4-chlorphenyl) propyl sulfate hydrochloride and carbon disulfide in a reaction flask under the normal-pressures

Catalyst free synthesis of mono- and disubstituted pyrimidines from O-acyl oximes

Transition-metal or iodine catalyzed transformations of O-acyl oximes to various N-heterocycles are well established. Herein, we report a catalyst free, oxime carboxylate based, three-component condensation method to access mono- and disubstituted pyrimidines. A broad range of substituted pyrimidines were prepared in moderate to excellent yields. Control experiments reveal that in situ generated formamidine is the key intermediate.

Asymmetric Nitrone Synthesis via Ligand-Enabled Copper-Catalyzed Cope-Type Hydroamination of Cyclopropene with Oxime

We report realization of the first enantioselective Cope-type hydroamination of oximes for asymmetric nitrone synthesis. The ligand promoted asymmetric cyclopropene "hydronitronylation" process employs a Cu-based catalytic system and readily available starting materials, operates under mild conditions and displays broad scope and exceptionally high enantio- and diastereocontrol. Preliminary mechanistic studies corroborate a CuI-catalytic profile featuring an olefin metalla-retro-Cope aminocupration process as the key C-N bond forming event. This conceptually novel reactivity enables the first example of highly enantioselective catalytic nitrone formation process and will likely spur further developments that may significantly expedite chiral nitrone synthesis.

NITROGENATED HETEROCYCLIC COMPOUND

The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

B(C6F5)3-catalyzed hydrogenation of oxime ethers without cleavage of the N-O bond

The hydrogenation of oximes and oxime ethers is usually hampered by N-O bond cleavage, hence affording amines rather than hydroxylamines. The boron Lewis acid B(C6F5)3 is found to catalyze the chemoselective hydrogenation

N, N′-dioxide-Cu(OTf)2 complex catalyzed highly enantioselective amination reaction of N-acetyl enamide

The N,N′-dioxide-Cu(OTf)2 complexes were applied in the asymmetric amination reaction of N-acetyl enamides with dialkyl azodicarboxylate, giving the corresponding products in good yields with high enantioselectivities (up to 91% ee). Precursors of vicinal diamine were readily obtained with excellent diastereoselectivities (>95:5) by NaBH4 reduction.

Enantioselective Strecker reaction of phosphinoyl ketoimines catalyzed by in situ prepared chiral N,N′-dioxides

The enantioselective Strecker reaction of N-diphenylphosphinoyl ketoimines has been achieved by use of in situ prepared chiral N,N′-dioxide catalyst from L-piperidinamide 3f and m-chloroperoxybenzoic acid (m-CPBA). Excellent yields (up to 99%) and high enantioselectivities (up to 92% ee) were obtained. In particular, in situ prepared catalyst with readily available chiral material made the procedure more convenient. Moreover, the L-piperidinamide 3f-derived N,N′-dioxide 9 could be recycled and reused at least five times without any loss of either catalytic activity or enantioselectivity.

4,4,5,5, Tetrasubstituted imidazolines

There is provided a compound of formula I and the pharmaceutically acceptable salts and esters thereof wherein X1, X2, R1, R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents.