1-(2-(2-chloropyrimidin-4-yloxy)-5-(trifluoromethyl)benzyl)-3-(3-t-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea

Base Information

• Chemical Name: 1-(2-(2-chloropyrimidin-4-yloxy)-5-(trifluoromethyl)benzyl)-3-(3-t-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea
• CAS No.: 940870-86-0
• Molecular Formula: C₂₇H₂₆ClF₃N₆O₂
• Molecular Weight: 558.991

Synonyms:1-(2-(2-chloropyrimidin-4-yloxy)-5-(trifluoromethyl)benzyl)-3-(3-t-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea

Chemical Property of 1-(2-(2-chloropyrimidin-4-yloxy)-5-(trifluoromethyl)benzyl)-3-(3-t-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea

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Technology Process of 1-(2-(2-chloropyrimidin-4-yloxy)-5-(trifluoromethyl)benzyl)-3-(3-t-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea

There total 3 articles about 1-(2-(2-chloropyrimidin-4-yloxy)-5-(trifluoromethyl)benzyl)-3-(3-t-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2,6-Dichloropyrimidine (3934-20-1) + 1-(2-hydroxy-5-(trifluoromethyl)benzyl)-3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea (940875-32-1) → 1-(2-(2-chloropyrimidin-4-yloxy)-5-(trifluoromethyl)benzyl)-3-(3-t-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea (940870-86-0)

Guidance literature:

With sodium hydroxide; In water; acetic acid; at 20 ℃; for 88h;

Reference yield:

2,2,2-trichloroethyl 3-tert-butyl-1-p-tolyl-1H-pyrazol-5-ylcarbamate (317806-87-4) → 1-(2-(2-chloropyrimidin-4-yloxy)-5-(trifluoromethyl)benzyl)-3-(3-t-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea (940870-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 60 °C

2: sodium hydroxide / water; acetone / 20 °C

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In water; acetone; acetonitrile;

DOI:10.1016/j.bmcl.2012.05.095

Reference yield:

2-(aminomethyl)-4-(trifluoromethyl)phenol (940875-31-0) → 1-(2-(2-chloropyrimidin-4-yloxy)-5-(trifluoromethyl)benzyl)-3-(3-t-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea (940870-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 60 °C

2: sodium hydroxide / water; acetone / 20 °C

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In water; acetone; acetonitrile;

DOI:10.1016/j.bmcl.2012.05.095

upstream raw materials:

2,6-Dichloropyrimidine

1-(2-hydroxy-5-(trifluoromethyl)benzyl)-3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea

2,2,2-trichloroethyl 3-tert-butyl-1-p-tolyl-1H-pyrazol-5-ylcarbamate

2-(aminomethyl)-4-(trifluoromethyl)phenol

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