317806-87-4

Basic information

• Product Name: 2,2,2-trichloroethyl 3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-ylcarbamate
• Synonyms: 2,2,2-trichloroethyl 3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-ylcarbamate
• CAS NO: 317806-87-4
• Molecular Formula: C₁₇H₂₀Cl₃N₃O₂
• Molecular Weight: 405
• Mol File: 317806-87-4.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 439.996°C at 760 mmHg
• Flash Point: 219.902°C
• Appearance: /
• Density: 1.312g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,2,2-trichloroethyl 3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trichloroethyl 3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-ylcarbamate(317806-87-4)
• EPA Substance Registry System: 2,2,2-trichloroethyl 3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-ylcarbamate(317806-87-4)

Safety Data

• Hazardous Substances Data: 317806-87-4(Hazardous Substances Data)

Usage

Derived from pyrazole

The compound is a derivative of pyrazole, which is a five-membered heterocyclic aromatic ring.

Commonly used as a pesticide, insecticide, or herbicide

The compound is widely used in agriculture and horticulture to control pests and unwanted plants due to its ability to inhibit their growth and reproduction.

Toxic to aquatic life with long-lasting effects

The compound can have harmful effects on aquatic life, and its impact can last for an extended period, making it a potential environmental hazard.

Should be handled and disposed of with care

Due to its potential environmental and health risks, the compound should be used, handled, and disposed of carefully to avoid contamination and harm to wildlife and humans.

May present health risks to humans if not used properly

The compound can pose health risks to humans if not used or handled correctly, and appropriate safety precautions must be taken to minimize these risks.

InChI:InChI=1/C17H20Cl3N3O2/c1-11-5-7-12(8-6-11)23-14(9-13(22-23)16(2,3)4)21-15(24)25-10-17(18,19)20/h5-9H,10H2,1-4H3,(H,21,24)

Upstream product

• 539-44-6 N-4-methylphenylhydrazine 
• 59997-51-2 trimethylacetylacetonitrile 
• 637-60-5 p-tolylhydrazine hydrochloride 
• 285984-25-0 3-tert-butyl-1-p-tolyl-1H-pyrazol-5-amine 
• 17341-93-4 2,2,2-Trichloroethyl chloroformate 
• 317806-86-3 3-amino-5-tert-butyl-2-(p-tolyl)-2H-pyrazole hydrochloride 

Downstream Products

• 285983-48-4 BIRB-796 
• 925899-74-7 tert-butyl 4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)phenylcarbamate 
• 1443251-66-8 N-(4-{(1R,4S)-4-[3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)ureido]-1,2,3,4-tetrahydronaphthalen-1-yloxymethyl}pyridin-2-yl)-2-methoxyacetamide 
• 1025919-11-2 1-[3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl]-3-(4-{6-[(3-methoxypropyl)methylamino]pyridin-3-yl}naphthalen-1-yl)urea 
• 294848-51-4 1-[3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl]-3-{4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl} urea 
• 1082294-38-9 N-{5-[({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]amino}carbonyl)amino]-2-methylphenyl}-1-(2,6-dichlorophenyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide 
• 1082296-45-4 1-(3-amino-4-methylphenyl)-3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea 

Relevant articles and documents

POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES

The current invention provides urea derivatives, in particular compounds having the core structure heteroaryl-NH-CO-NH-aryl-O- heteroaryl, for use in treating, ameliorating, delaying, curing and/ or preventing a disease or condition associated with muscle cells and/or satellite cells, such as Duchenne muscular dystrophy, Becker muscular dystrophy, cachexia or sarcopenia.

Novel diaryl urea compounds, and preparation method and medical applications thereof

The invention relates to compounds represented by the formula (I), and isomers, pharmaceutically acceptable salts, and solvates thereof. The invention further relates to a composition, which comprises abovementioned compounds, isomers, salts, and solvates, and a pharmaceutically acceptable carrier, excipient, or diluent; and applications of abovementioned compounds, isomers, salts, and solvates in treating diseases and symptoms of acute lung injury caused by inflammation, diseases related with inflammation, tumor, suffocating gas, and irritant gas, especially an application of treating P38MAPK related diseases and symptoms.

Synthesis and p38 inhibitory activity of some novel substituted N,N′-diarylurea derivatives

We have identified a novel series of substituted N,N′-diarylurea p38α inhibitors. The inhibitory activity of the target compounds against the enzyme p38α, MAPKAPK2 in BHK cells, TNF-α release in LPS-stimulated THP-1 cells and p38α binding experiments were