3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetic acid

Base Information

Chemical Name:3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetic acid
CAS No.:119487-54-6
Molecular Formula:C₂₄H₁₉ClN₄O₄
Molecular Weight:462.892
Hs Code.:

Synonyms:3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetic acid

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Chemical Property of 3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetic acid

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Technology Process of 3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetic acid

There total 5 articles about 3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 118018-39-6
ethyl 3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate

: 119487-54-6
3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 23 ℃; for 3h;
DOI:10.1021/jm00078a018

Reference yield:

: 108895-98-3
benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

: 119487-54-6
3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 2 h, 2.) DMF, from 0 deg C to RT, 1 h

2: 100 percent / 10percent Pd/C / methanol / 1.5 h

3: 76 percent / tetrahydrofuran / Ambient temperature

4: 58 percent / 1 N aq. NaOH / tetrahydrofuran / 3 h / 23 °C

With sodium hydroxide; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm00078a018

Reference yield:

: 119487-58-0
ethyl 3-<(benzyloxycarbonyl)amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate

: 119487-54-6
3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / 10percent Pd/C / methanol / 1.5 h

2: 76 percent / tetrahydrofuran / Ambient temperature

3: 58 percent / 1 N aq. NaOH / tetrahydrofuran / 3 h / 23 °C

With sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm00078a018