6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one benzenesulfonate

Base Information

• Chemical Name: 6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one benzenesulfonate
• CAS No.: 1176326-78-5
• Molecular Formula: C₆H₆O₃S*C₂₆H₃₂BrNO₄
• Molecular Weight: 660.626
• Mol file: 1176326-78-5.mol

Synonyms:6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one benzenesulfonate

Chemical Property of 6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one benzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one benzenesulfonate

There total 5 articles about 6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-(4-Oxo-3,4-dihydro-2H-chromen-6-yl)ethyl benzenesulfonate (1176327-46-0) + 4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidine hydrochloride (1176327-20-0) + benzenesulfonic acid (98-11-3) → 6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one benzenesulfonate (1176326-78-5)

Guidance literature:

4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidine hydrochloride; With potassium hydroxide; In water; toluene;

2-(4-Oxo-3,4-dihydro-2H-chromen-6-yl)ethyl benzenesulfonate; With 1-methyl-pyrrolidin-2-one; dipotassium hydrogen phosphate; In toluene; at 110 - 120 ℃; for 6h;

benzenesulfonic acid; In acetone; at 50 - 60 ℃;

Reference yield: 88.0%

6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one (1176326-76-3) + benzenesulfonic acid (98-11-3) → 6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one benzenesulfonate (1176326-78-5)

Guidance literature:

In water; acetone; at 40 - 45 ℃; Product distribution / selectivity;

Reference yield: 79.0%

2-(4-Oxo-3,4-dihydro-2H-chromen-6-yl)ethyl benzenesulfonate (1176327-46-0) + 4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidine hydrochloride (1176327-20-0) + ammonium benzenesulfonate (19402-64-3) → 6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one benzenesulfonate (1176326-78-5)

Guidance literature:

4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidine hydrochloride; With potassium hydroxide; In water; toluene;

2-(4-Oxo-3,4-dihydro-2H-chromen-6-yl)ethyl benzenesulfonate; With 1-methyl-pyrrolidin-2-one; dipotassium hydrogen phosphate; In toluene; at 110 - 120 ℃; for 6.5h;

ammonium benzenesulfonate; In acetone; at 40 - 50 ℃;

upstream raw materials:

6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one

benzenesulfonic acid

2-(4-Oxo-3,4-dihydro-2H-chromen-6-yl)ethyl benzenesulfonate

4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidine hydrochloride

Refernces