6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one

Base Information

Chemical Name:6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one
CAS No.:1176326-76-3
Molecular Formula:C₂₆H₃₂BrNO₄
Molecular Weight:502.448
Hs Code.:

Synonyms:6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one

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Chemical Property of 6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one

There total 17 articles about 6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1176327-20-0
4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidine hydrochloride

: 1176327-37-9
2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl 4-methylbenzenesulfonate

: 1176326-76-3
6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one

Guidance literature:: 4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidine hydrochloride; With potassium carbonate; In water;

2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl 4-methylbenzenesulfonate; With potassium carbonate; In acetonitrile; at 70 - 80 ℃; for 7h;

Reference yield: 100.0%

: 1176327-47-1
4-[4-Bromo-3-(2-methoxyethoxy)benzyl]piperidine

: 1176327-37-9
2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl 4-methylbenzenesulfonate

: 1176326-76-3
6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one

Guidance literature:: With potassium carbonate; In acetonitrile; at 70 - 80 ℃; for 7h;

Reference yield:

: 145760-35-6
methyl [4-(3-hydroxypropoxy)phenyl]acetate

: 1176326-76-3
6-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hypochlorite; disodium hydrogenphosphate; potassium dihydrogenphosphate; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile; water / 3 h / 20 - 25 °C

2.1: thionyl chloride / toluene / 3 h / 60 °C

3.1: aluminum (III) chloride / dichloromethane / 2 h / 20 - 25 °C

3.2: 15 °C

4.1: toluene-4-sulfonic acid / methanol / 20 h / 15 - 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 30 °C

5.2: 15 °C

5.3: 15 - 25 °C

6.1: triethylamine / trimethylamine hydrochloride / acetonitrile / 5 - 15 °C

7.1: potassium carbonate / water

7.2: 7 h / 70 - 80 °C

With aluminum (III) chloride; sodium hypochlorite; sodium chlorite; disodium hydrogenphosphate; potassium dihydrogenphosphate; lithium aluminium tetrahydride; thionyl chloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium carbonate; triethylamine; trimethylamine hydrochloride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;