(3R,7R,8S,8aR)-7-Allyl-8-ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester

Base Information

• Chemical Name: (3R,7R,8S,8aR)-7-Allyl-8-ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester
• CAS No.: 457622-97-8
• Molecular Formula: C₂₆H₂₉NO₄
• Molecular Weight: 419.521
• Mol file: 457622-97-8.mol

Synonyms:(3R,7R,8S,8aR)-7-Allyl-8-ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester

Chemical Property of (3R,7R,8S,8aR)-7-Allyl-8-ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3R,7R,8S,8aR)-7-Allyl-8-ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester

There total 1 articles about (3R,7R,8S,8aR)-7-Allyl-8-ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

allytriphenyltin (76-63-1) + 8-ethyl-5-oxo-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester (331473-26-8) → (3R,7R,8S,8aR)-7-Allyl-8-ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester (457622-97-8)

Guidance literature:

With copper(l) iodide; chloro-trimethyl-silane; phenyllithium; lithium chloride; In tetrahydrofuran;

DOI:10.1021/ol0263245

Reference yield:

(3R,7R,8S,8aR)-7-Allyl-8-ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester (457622-97-8) → ((3R,7R,8S,8aR)-8-Ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-7-yl)-acetic acid ethyl ester (457622-98-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ozone / CH₂Cl₂; methanol

1.2: dimethyl sulfide / CH₂Cl₂; methanol

2.1: pyridinium dichromate / dimethylformamide

3.1: trimethylsilyl chloride

4.1: hydrogen / 10percent Pd/C

4.2: 82 percent / toluene / Heating

With dipyridinium dichromate; chloro-trimethyl-silane; hydrogen; ozone; 10percent Pd/C; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol0263245

Reference yield:

(3R,7R,8S,8aR)-7-Allyl-8-ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester (457622-97-8) → [(3S,4R)-3-Ethyl-1-((R)-2-hydroxy-1-phenyl-ethyl)-piperidin-4-yl]-acetic acid ethyl ester (457622-99-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: ozone / CH₂Cl₂; methanol

1.2: dimethyl sulfide / CH₂Cl₂; methanol

2.1: pyridinium dichromate / dimethylformamide

3.1: trimethylsilyl chloride

4.1: hydrogen / 10percent Pd/C

4.2: 82 percent / toluene / Heating

5.1: 66 percent / BH₃*THF

With dipyridinium dichromate; chloro-trimethyl-silane; borane-THF; hydrogen; ozone; 10percent Pd/C; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol0263245

upstream raw materials:

allytriphenyltin

8-ethyl-5-oxo-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester

Downstream raw materials:

-essigsaeure-ethylester

[(3S,4R)-3-Ethyl-1-((R)-2-hydroxy-1-phenyl-ethyl)-piperidin-4-yl]-acetic acid ethyl ester

((3R,7R,8S,8aR)-8-Ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-7-yl)-acetic acid ethyl ester