((3R,7R,8S,8aR)-8-Ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-7-yl)-acetic acid ethyl ester

Base Information

Chemical Name:((3R,7R,8S,8aR)-8-Ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-7-yl)-acetic acid ethyl ester
CAS No.:457622-98-9
Molecular Formula:C₁₉H₂₅NO₄
Molecular Weight:331.412
Hs Code.:

Synonyms:((3R,7R,8S,8aR)-8-Ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-7-yl)-acetic acid ethyl ester

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Chemical Property of ((3R,7R,8S,8aR)-8-Ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-7-yl)-acetic acid ethyl ester

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of ((3R,7R,8S,8aR)-8-Ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-7-yl)-acetic acid ethyl ester

There total 5 articles about ((3R,7R,8S,8aR)-8-Ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-7-yl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: (3R,7R,8S,8aR)-7-Ethoxycarbonylmethyl-8-ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester

: 457622-98-9
((3R,7R,8S,8aR)-8-Ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-7-yl)-acetic acid ethyl ester

Guidance literature:: (3R,7R,8S,8aR)-7-Ethoxycarbonylmethyl-8-ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester; With hydrogen; 10percent Pd/C;

In toluene; Further stages.; Heating;
DOI:10.1021/ol0263245

Reference yield:

: 331473-26-8
8-ethyl-5-oxo-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester

: 457622-98-9
((3R,7R,8S,8aR)-8-Ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-7-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 86 percent / phenyllithium; copper(I) iodide; trimethylsilyl chloride / lithium chloride / tetrahydrofuran

2.1: ozone / CH₂Cl₂; methanol

2.2: dimethyl sulfide / CH₂Cl₂; methanol

3.1: pyridinium dichromate / dimethylformamide

4.1: trimethylsilyl chloride

5.1: hydrogen / 10percent Pd/C

5.2: 82 percent / toluene / Heating

With copper(l) iodide; dipyridinium dichromate; chloro-trimethyl-silane; hydrogen; ozone; phenyllithium; lithium chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0263245

Reference yield:

: (3R,7R,8S,8aR)-8-Ethyl-5-oxo-7-(2-oxo-ethyl)-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester

: 457622-98-9
((3R,7R,8S,8aR)-8-Ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-7-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium dichromate / dimethylformamide

2.1: trimethylsilyl chloride

3.1: hydrogen / 10percent Pd/C

3.2: 82 percent / toluene / Heating

With dipyridinium dichromate; chloro-trimethyl-silane; hydrogen; 10percent Pd/C; In N,N-dimethyl-formamide;
DOI:10.1021/ol0263245