2-AMINOMETHYL-3H-QUINAZOLIN-4-ONE

Base Information

• Chemical Name: 2-AMINOMETHYL-3H-QUINAZOLIN-4-ONE
• CAS No.: 437998-08-8
• Molecular Formula: C9H9 N3 O
• Molecular Weight: 175.19
• Hs Code.: 2933990090
• Mol file: 437998-08-8.mol

Synonyms:4(1H)-Quinazolinone,2-(aminomethyl)- (9CI); 2-(Aminomethyl)quinazolin-4(3H)-one

Chemical Property of 2-AMINOMETHYL-3H-QUINAZOLIN-4-ONE

Chemical Property:

• Vapor Pressure: 4.44E-05mmHg at 25°C
• Refractive Index: 1.698
• Boiling Point: 350.3°C at 760 mmHg
• Flash Point: 165.7°C
• PSA: 71.77000
• Density: 1.41g/cm³
• LogP: 1.08210

Purity/Quality:

98%min ^*data from raw suppliers

2-(aminomethyl)quinazolin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINOMETHYL-3H-QUINAZOLIN-4-ONE

There total 9 articles about 2-AMINOMETHYL-3H-QUINAZOLIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-(azidomethyl)quinazolin-4(3H)-one (1247556-32-6) → 2-(aminomethyl)quinazolin-4(3H)-one (437998-08-8)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; water; at 20 ℃; for 19h; Inert atmosphere;

DOI:10.1021/jm401394u

Reference yield:

anthranilic acid amide (28144-70-9,88-68-6) → 2-(aminomethyl)quinazolin-4(3H)-one (437998-08-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 0 - 10 °C

1.2: 0 - 10 °C

1.3: 16 h / 25 - 35 °C

2.1: sodium hydroxide / ethanol; water / 16 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 5 h / Reflux

With triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

(4-oxo-3,4-dihydroquinazolin-2-ylmethyl)carbamic acid tert-butyl ester (1206450-57-8) → 2-(aminomethyl)quinazolin-4(3H)-one (437998-08-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 5h; Reflux;

upstream raw materials:

anthranilic acid nitrile

2-methoxyacetamidobenzonitrile

2-methoxymethylquinazolin-4(3H)-one

2-(hydroxymethyl)quinazolin-4(3H)-one

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