1-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Name:1-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:258501-33-6
Molecular Formula:C₂₉H₃₉N₃O₇Si
Molecular Weight:569.73
Hs Code.:

1-{5-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(<i>N</i>-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-5-methyl-1<i>H</i>-pyrimidine-2,4-dione

Synonyms:1-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

There total 10 articles about 1-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 212061-26-2
2'-O-[(2-formadoxyiminooxy)ethyl]-5'-O-tert-butyldiphenylsilyl-5-methyluridine

: 258501-33-6
1-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With pyridinium p-toluenesulfonate; sodium cyanoborohydride; In methanol; at 10 - 20 ℃; for 2.16667h;

Reference yield:

: 22423-26-3
O-2,2'-cyclo-5-methyluridine

: 258501-33-6
1-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 74.8 percent / DMAP / pyridine / 16 h / 20 °C

2: BH₃*THF; NaHCO₃ / 16 h / 160 °C

3: 86 percent / PPh₃; DEAD / tetrahydrofuran / 4 h / 20 °C

4: N-methylhydrazine / CH₂Cl₂ / 1 h / -10 - 0 °C

5: 7.71 g / methanol; H₂O / 5 h / 20 °C

6: pyridinium p-toluenesulfonate; NaBH₃CN / methanol / 0 - 20 °C

With dmap; borane-THF; pyridinium p-toluenesulfonate; sodium cyanoborohydride; sodium hydrogencarbonate; triphenylphosphine; methylhydrazine; diethylazodicarboxylate; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; 3: Mitsunobu reaction;
DOI:10.1021/jo0103975

Reference yield:

: 212061-25-1
5'-O-(tert-butyldiphenylsilyl)-2'-O-[2-[(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)oxy]ethyl]-5-methyluridine

: 258501-33-6
1-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: methylhydrazine / CH₂Cl₂ / 1 h / -10 - 0 °C

2: methanol / 20 °C

3: pyridinium p-toluenesulfonate; NaBH₃CN / methanol / 2.17 h / 10 - 20 °C

With pyridinium p-toluenesulfonate; sodium cyanoborohydride; methylhydrazine; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(03)01104-9