4-Isopropoxy-3-[4-(1-methyl-1H-benzoimidazol-5-yl)-thiazol-2-ylamino]-benzamide

Base Information

• Chemical Name: 4-Isopropoxy-3-[4-(1-methyl-1H-benzoimidazol-5-yl)-thiazol-2-ylamino]-benzamide
• CAS No.: 1378022-72-0
• Molecular Formula: C₂₁H₂₁N₅O₂S
• Molecular Weight: 407.496
• Mol file: 1378022-72-0.mol

Synonyms:4-Isopropoxy-3-[4-(1-methyl-1H-benzoimidazol-5-yl)-thiazol-2-ylamino]-benzamide

Chemical Property of 4-Isopropoxy-3-[4-(1-methyl-1H-benzoimidazol-5-yl)-thiazol-2-ylamino]-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Isopropoxy-3-[4-(1-methyl-1H-benzoimidazol-5-yl)-thiazol-2-ylamino]-benzamide

There total 9 articles about 4-Isopropoxy-3-[4-(1-methyl-1H-benzoimidazol-5-yl)-thiazol-2-ylamino]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Isopropoxy-3-thioureido-benzamide (1377581-88-8) + 2-bromo-1-(1-methyl-1H-benzimidazol-5-yl)ethanone hydrobromide → 4-Isopropoxy-3-[4-(1-methyl-1H-benzoimidazol-5-yl)-thiazol-2-ylamino]-benzamide (1378022-72-0)

Guidance literature:

4-Isopropoxy-3-thioureido-benzamide; 2-bromo-1-(1-methyl-1H-benzimidazol-5-yl)ethanone hydrobromide; In ethanol; at 20 ℃; for 24h;

With ammonia; In methanol; ethanol;

Reference yield:

4-fluoro-3-nitrobenzamide (349-02-0) → 4-Isopropoxy-3-[4-(1-methyl-1H-benzoimidazol-5-yl)-thiazol-2-ylamino]-benzamide (1378022-72-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 5 h / 0 - 23 °C

2.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 1 h / 0 - 23 °C

2.2: 0 °C

3.1: sodium carbonate / chloroform; water / 3.17 h / 20 °C

4.1: ammonia / methanol / 16 h / 20 °C

5.1: ethanol / 24 h / 20 °C

With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; ammonia; potassium hexamethylsilazane; sodium carbonate; In tetrahydrofuran; methanol; ethanol; chloroform; water; toluene;

Reference yield:

3-nitro-4-fluorobenzoic acid (453-71-4) → 4-Isopropoxy-3-[4-(1-methyl-1H-benzoimidazol-5-yl)-thiazol-2-ylamino]-benzamide (1378022-72-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: thionyl chloride / water / 3 h / 80 °C

1.2: 0.58 h / 0 °C / Cooling with ice

2.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 5 h / 0 - 23 °C

3.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 1 h / 0 - 23 °C

3.2: 0 °C

4.1: sodium carbonate / chloroform; water / 3.17 h / 20 °C

5.1: ammonia / methanol / 16 h / 20 °C

6.1: ethanol / 24 h / 20 °C

With methanol; sodium tetrahydroborate; thionyl chloride; nickel(II) chloride hexahydrate; ammonia; potassium hexamethylsilazane; sodium carbonate; In tetrahydrofuran; methanol; ethanol; chloroform; water; toluene;

upstream raw materials:

4-fluoro-3-nitrobenzamide

3-nitro-4-fluorobenzoic acid

N-methoxy-N,1-dimethyl-1H-benzo[d]imidazole-5-carboxamide

1-(1-methyl-1H-benzo[d]imidazol-5-yl)ethan-1-one