1H-Pyrrole-3-acetonitrile,5-cyano-alpha-hydroxy-1-methyl-,(alphaR)-(9CI)

Base Information

• Chemical Name: 1H-Pyrrole-3-acetonitrile,5-cyano-alpha-hydroxy-1-methyl-,(alphaR)-(9CI)
• CAS No.: 437709-71-2
• Molecular Formula: C₈H₇N₃O
• Molecular Weight: 161.163
• Mol file: 437709-71-2.mol

Synonyms:1H-Pyrrole-3-acetonitrile,5-cyano-alpha-hydroxy-1-methyl-,(alphaR)-(9CI)

Chemical Property of 1H-Pyrrole-3-acetonitrile,5-cyano-alpha-hydroxy-1-methyl-,(alphaR)-(9CI)

Chemical Property:

• Boiling Point: 377.3±42.0 °C(Predicted)
• PKA: 10.38±0.20(Predicted)
• Density: 1.20±0.1 g/cm3(Predicted)

Purity/Quality:

(aR)-5-cyano-a-hydroxy-1-methyl-1H-Pyrrole-3-acetonitrile 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrole-3-acetonitrile,5-cyano-alpha-hydroxy-1-methyl-,(alphaR)-(9CI)

There total 3 articles about 1H-Pyrrole-3-acetonitrile,5-cyano-alpha-hydroxy-1-methyl-,(alphaR)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium cyanide (151-50-8) + 4-formyl-1-methyl-1H-pyrrol-2-carbonitrile (119580-81-3) → 2-hydroxy-2-(5-cyano-1-methyl-3-pyrrolyl)acetonitrile (437709-71-2)

Guidance literature:

4-formyl-1-methyl-1H-pyrrol-2-carbonitrile; With sodium hydrogensulfite; In diethyl ether; at 0 ℃; for 1h;

potassium cyanide; In diethyl ether; water; at 0 - 30 ℃;

DOI:10.1016/S0957-4166(02)00005-8

Reference yield:

hydrogen cyanide (74-90-8) + 4-formyl-1-methyl-1H-pyrrol-2-carbonitrile (119580-81-3) → (S)-2-hydroxy-2-(5-cyano-1-methyl-3-pyrrolyl)acetonitrile (437709-71-2) + (R)-(+)-2-hydroxy-2-(5-cyano-1-methyl-3-pyrrolyl)acetonitrile (437709-71-2)

Guidance literature:

With almond meal ((R)-oxynitrilase); In di-isopropyl ether; at 4 - 30 ℃; Title compound not separated from byproducts;

DOI:10.1016/S0957-4166(02)00005-8

Reference yield:

hydrogen cyanide (74-90-8) + 4-formyl-1-methyl-1H-pyrrol-2-carbonitrile (119580-81-3) → (S)-2-hydroxy-2-(5-cyano-1-methyl-3-pyrrolyl)acetonitrile (437709-71-2) + (R)-(+)-2-hydroxy-2-(5-cyano-1-methyl-3-pyrrolyl)acetonitrile (437709-71-2)

Guidance literature:

With almond meal ((R)-oxynitrilase); In di-isopropyl ether; at 4 - 30 ℃; Title compound not separated from byproducts;

DOI:10.1016/S0957-4166(02)00005-8

upstream raw materials:

potassium cyanide

4-formyl-1-methyl-1H-pyrrol-2-carbonitrile

hydrogen cyanide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 437709-71-2 1H-Pyrrole-3-acetonitrile,5-cyano-alpha-hydroxy-1-methyl-,(alphaR)-(9CI)

Send

Send

Metric Ton KG G Pound L ML

Send

Send