4-Chloro-6-nitro-2-(piperazin-1-YL)quinoline

Base Information

Chemical Name:4-Chloro-6-nitro-2-(piperazin-1-YL)quinoline
CAS No.:437708-76-4
Molecular Formula:C₁₃H₁₃ClN₄O₂
Molecular Weight:292.725
Hs Code.:
DSSTox Substance ID:DTXSID00438329
Nikkaji Number:J1.680.754K
Wikidata:Q82254030
ChEMBL ID:CHEMBL423269
Mol file:437708-76-4.mol

Synonyms:4-CHLORO-6-NITRO-2-(PIPERAZIN-1-YL)QUINOLINE;437708-76-4;CHEMBL423269;4-chloro-6-nitro-2-piperazin-1-yl-quinoline;D0P0US;SCHEMBL6365676;DTXSID00438329;BDBM50110578;2-Piperazino-4-chloro-6-nitroquinoline;PD182121

Suppliers and Price of 4-Chloro-6-nitro-2-(piperazin-1-YL)quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-CHLORO-6-NITRO-2-(PIPERAZIN-1-YL)QUINOLINE 98.00%
5MG
$ 497.77

Total 3 raw suppliers

Chemical Property of 4-Chloro-6-nitro-2-(piperazin-1-YL)quinoline

Chemical Property:

PSA：73.98000
LogP:3.12300
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:292.0727034
Heavy Atom Count:20
Complexity:359

Purity/Quality:

97% ^*data from raw suppliers

4-CHLORO-6-NITRO-2-(PIPERAZIN-1-YL)QUINOLINE 98.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1)C2=NC3=C(C=C(C=C3)[N+](=O)[O-])C(=C2)Cl

Technology Process of 4-Chloro-6-nitro-2-(piperazin-1-YL)quinoline

There total 8 articles about 4-Chloro-6-nitro-2-(piperazin-1-YL)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 437708-89-9
4-(4-chloro-6-nitro-quinolin-2-yl)-piperazine-1-carbaldehyde

: 437708-76-4
4-chloro-6-nitro-2-piperazin-1-yl-quinoline

Guidance literature:: With sulfuric acid; In tetrahydrofuran; at 80 ℃; for 3h;
DOI:10.1016/S0960-894X(02)00028-8

Reference yield:

: 10390-08-6
ethyl 3-((4-nitrophenyl)amino)-3-oxopropanoate

: 437708-76-4
4-chloro-6-nitro-2-piperazin-1-yl-quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: polyphosphoric acid / 2.5 h / 120 °C

2: phosphorus oxychloride / 2.5 h / 80 °C

3: 0 °C

With PPA; trichlorophosphate;
DOI:10.1016/j.bmc.2005.05.031

Reference yield:

: 408523-59-1
2,4-dichloro-6-nitroquinoline

: 437708-76-4
4-chloro-6-nitro-2-piperazin-1-yl-quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylformamide / 3 h / 60 °C

2: aq. H₂SO₄ / tetrahydrofuran / 3 h / 80 °C

With sulfuric acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00028-8