2,4-Dichloro-6-nitroquinoline

Base Information

• Chemical Name: 2,4-Dichloro-6-nitroquinoline
• CAS No.: 408523-59-1
• Molecular Formula: C9H4Cl2N2O2
• Molecular Weight: 243.04600
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID40698167
• Nikkaji Number: J1.680.752D
• Wikidata: Q82628293
• Mol file: 408523-59-1.mol

Synonyms:2,4-DICHLORO-6-NITROQUINOLINE;408523-59-1;SCHEMBL4658369;DTXSID40698167;ZHHMYLFTTXCPRJ-UHFFFAOYSA-N;MFCD08234680;AKOS015851260;SB71510;BS-51586;CS-0155653;FT-0717775;C75070;EN300-134181;Z1509589546

Chemical Property of 2,4-Dichloro-6-nitroquinoline

Chemical Property:

• PSA: 58.71000
• LogP: 3.97300
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 241.9649828
• Heavy Atom Count: 15
• Complexity: 259

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dichloro-6-nitroquinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=C1[N+](=O)[O-])C(=CC(=N2)Cl)Cl

Technology Process of 2,4-Dichloro-6-nitroquinoline

There total 12 articles about 2,4-Dichloro-6-nitroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4-hydroxy-6-nitroquinolin-2(1H)-one (264260-06-2) → 2,4-dichloro-6-nitroquinoline (408523-59-1)

Guidance literature:

With trichlorophosphate; for 6h; Heating;

DOI:10.1016/S0960-894X(02)00028-8

Reference yield: 55.0%

2-amino-5-nitrophenylacetylene (125600-42-2) + trichloromethyl chloroformate (503-38-8) → 2,4-dichloro-6-nitroquinoline (408523-59-1)

Guidance literature:

In acetonitrile; at 150 ℃; for 12h;

DOI:10.1055/s-2005-922790

Reference yield:

6-nitro-quinoline-2,4-diol (264260-06-2) → 2,4-dichloro-6-nitroquinoline (408523-59-1)

Guidance literature:

With trichlorophosphate; at 80 ℃; for 2h;

upstream raw materials:

4,6-dichloroquinoline 1-oxide

4,6-Dinitro-chinolin-1-oxyd

trichlorophosphate

4-hydroxy-6-nitroquinolin-2(1H)-one

Downstream raw materials:

4-chloro-6-nitro-2-piperazin-1-yl-quinoline