(+)-5'-O-(4,4'-dimethoxytrityl)-6-[2-(methoxycarbonyl)ethenyl]-2'-deoxyuridine

Base Information

Chemical Name:(+)-5'-O-(4,4'-dimethoxytrityl)-6-[2-(methoxycarbonyl)ethenyl]-2'-deoxyuridine
CAS No.:370595-47-4
Molecular Formula:C₃₄H₃₄N₂O₉
Molecular Weight:614.652
Hs Code.:

Synonyms:(+)-5'-O-(4,4'-dimethoxytrityl)-6-[2-(methoxycarbonyl)ethenyl]-2'-deoxyuridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-5'-O-(4,4'-dimethoxytrityl)-6-[2-(methoxycarbonyl)ethenyl]-2'-deoxyuridine

Chemical Property:

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Technology Process of (+)-5'-O-(4,4'-dimethoxytrityl)-6-[2-(methoxycarbonyl)ethenyl]-2'-deoxyuridine

There total 5 articles about (+)-5'-O-(4,4'-dimethoxytrityl)-6-[2-(methoxycarbonyl)ethenyl]-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 370595-46-3
(+)-6-[2-(methoxycarbonyl)ethenyl]-2'-deoxyuridine

: 370595-47-4
(+)-5'-O-(4,4'-dimethoxytrityl)-6-[2-(methoxycarbonyl)ethenyl]-2'-deoxyuridine

Guidance literature:: With pyridine; silver nitrate; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1016/S0040-4020(03)00875-5

Reference yield:

: 951-78-0,63844-76-8
2'-deoxyuridine

: 370595-47-4
(+)-5'-O-(4,4'-dimethoxytrityl)-6-[2-(methoxycarbonyl)ethenyl]-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / imidazole / dimethylformamide / 23 h / 20 °C

2.1: HMPA; LDA / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C

2.2: tetrahydrofuran; cyclohexane / 2 h / -78 °C

2.3: 52 percent / acetic acid / tetrahydrofuran; cyclohexane / -78 °C

3.1: 96 percent / benzene / 2 h / 20 °C

4.1: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.67 h / 20 °C

5.1: 76 percent / pyridine; silver nitrate / tetrahydrofuran / 5 h / 20 °C

With pyridine; 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; tetrabutyl ammonium fluoride; silver nitrate; lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; N,N-dimethyl-formamide; benzene; 3.1: Wittig reaction;
DOI:10.1016/S0040-4020(03)00875-5

Reference yield:

: 98495-56-8
3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine

: 370595-47-4
(+)-5'-O-(4,4'-dimethoxytrityl)-6-[2-(methoxycarbonyl)ethenyl]-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: HMPA; LDA / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C

1.2: tetrahydrofuran; cyclohexane / 2 h / -78 °C

1.3: 52 percent / acetic acid / tetrahydrofuran; cyclohexane / -78 °C

2.1: 96 percent / benzene / 2 h / 20 °C

3.1: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.67 h / 20 °C

4.1: 76 percent / pyridine; silver nitrate / tetrahydrofuran / 5 h / 20 °C

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; tetrabutyl ammonium fluoride; silver nitrate; lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; benzene; 2.1: Wittig reaction;
DOI:10.1016/S0040-4020(03)00875-5