(2E)-3-[3-(5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]-N-[6-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)hexyl]acrylamide

Base Information

Chemical Name:(2E)-3-[3-(5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]-N-[6-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)hexyl]acrylamide
CAS No.:370595-49-6
Molecular Formula:C₅₁H₅₂N₄O₉
Molecular Weight:864.995
Hs Code.:

(2E)-3-[3-(5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]-N-[6-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)hexyl]acrylamide

Synonyms:(2E)-3-[3-(5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]-N-[6-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)hexyl]acrylamide

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Chemical Property of (2E)-3-[3-(5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]-N-[6-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)hexyl]acrylamide

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Technology Process of (2E)-3-[3-(5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]-N-[6-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)hexyl]acrylamide

There total 13 articles about (2E)-3-[3-(5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]-N-[6-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)hexyl]acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 370595-47-4
(+)-5'-O-(4,4'-dimethoxytrityl)-6-[2-(methoxycarbonyl)ethenyl]-2'-deoxyuridine

: 6-(9H-carbazol-2-yloxy)hexylamine

: 370595-49-6
(2E)-3-[3-(5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]-N-[6-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)hexyl]acrylamide

Guidance literature:: (+)-5'-O-(4,4'-dimethoxytrityl)-6-[2-(methoxycarbonyl)ethenyl]-2'-deoxyuridine; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 2h;

6-(9H-carbazol-2-yloxy)hexylamine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0040-4020(03)00875-5

Reference yield:

: 370595-55-4
6-(9H-carbazol-2-yloxy)-hexylamine

: (E)-3-(3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-acrylic acid

: 370595-49-6
(2E)-3-[3-(5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]-N-[6-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)hexyl]acrylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1016/S0040-4039(01)01091-7

Reference yield:

: 951-78-0,63844-76-8
2'-deoxyuridine

: 370595-49-6
(2E)-3-[3-(5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]-N-[6-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)hexyl]acrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 100 percent / imidazole / dimethylformamide / 23 h / 20 °C

2.1: HMPA; LDA / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C

2.2: tetrahydrofuran; cyclohexane / 2 h / -78 °C

2.3: 52 percent / acetic acid / tetrahydrofuran; cyclohexane / -78 °C

3.1: 96 percent / benzene / 2 h / 20 °C

4.1: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.67 h / 20 °C

5.1: 76 percent / pyridine; silver nitrate / tetrahydrofuran / 5 h / 20 °C

6.1: LiOH*H₂O; H₂O / tetrahydrofuran / 2 h / 20 °C

6.2: 25 percent / triethylamine; N-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 20 °C

With pyridine; 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; tetrabutyl ammonium fluoride; water; silver nitrate; lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; N,N-dimethyl-formamide; benzene; 3.1: Wittig reaction;
DOI:10.1016/S0040-4020(03)00875-5