diethyl 2-<<2-amino-6-(4-chlorophenyl)sulfanyl>purin-9-yl>ethylmalonate

Base Information

Chemical Name:diethyl 2-<<2-amino-6-(4-chlorophenyl)sulfanyl>purin-9-yl>ethylmalonate
CAS No.:225111-69-3
Molecular Formula:C₂₀H₂₂ClN₅O₄S
Molecular Weight:463.945
Hs Code.:

Synonyms:diethyl 2-<<2-amino-6-(4-chlorophenyl)sulfanyl>purin-9-yl>ethylmalonate

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Chemical Property of diethyl 2-<<2-amino-6-(4-chlorophenyl)sulfanyl>purin-9-yl>ethylmalonate

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Technology Process of diethyl 2-<<2-amino-6-(4-chlorophenyl)sulfanyl>purin-9-yl>ethylmalonate

There total 4 articles about diethyl 2-<<2-amino-6-(4-chlorophenyl)sulfanyl>purin-9-yl>ethylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 105-53-3
diethyl malonate

: 225111-68-2
2-amino-9-(2-bromoethyl)-6-<(4-chlorophenyl)sulfanyl>-9H-purine

: 225111-69-3
diethyl 2-<<2-amino-6-(4-chlorophenyl)sulfanyl>purin-9-yl>ethylmalonate

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 50 ℃; for 1.5h;
DOI:10.1016/S0040-4020(99)00169-6

Reference yield:

: 73-40-5
2-amino-1,9-dihydro-6H-purin-6-one

: 225111-69-3
diethyl 2-<<2-amino-6-(4-chlorophenyl)sulfanyl>purin-9-yl>ethylmalonate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) trifluoroacetic anhydride / 1) pyridine, 0 deg C, 20 min; 2) pyridine, rt, 2 h

2: 86.6 percent / potassium carbonate / dimethylsulfoxide / 1 h / 50 °C

3: 93 percent / potassium carbonate / dimethylsulfoxide / 1.5 h / 50 °C

With potassium carbonate; trifluoroacetic anhydride; In dimethyl sulfoxide;
DOI:10.1016/S0040-4020(99)00169-6

Reference yield:

: 106-54-7
p-Chlorothiophenol

: 225111-69-3
diethyl 2-<<2-amino-6-(4-chlorophenyl)sulfanyl>purin-9-yl>ethylmalonate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) trifluoroacetic anhydride / 1) pyridine, 0 deg C, 20 min; 2) pyridine, rt, 2 h

2: 86.6 percent / potassium carbonate / dimethylsulfoxide / 1 h / 50 °C

3: 93 percent / potassium carbonate / dimethylsulfoxide / 1.5 h / 50 °C

With potassium carbonate; trifluoroacetic anhydride; In dimethyl sulfoxide;
DOI:10.1016/S0040-4020(99)00169-6