7-methyl-1-phenethyl-2,3-dihydro-1H-[1,8]naphthyridin-4-one O-oxiranylmethyl-oxime

Base Information

Chemical Name:7-methyl-1-phenethyl-2,3-dihydro-1H-[1,8]naphthyridin-4-one O-oxiranylmethyl-oxime
CAS No.:309728-77-6
Molecular Formula:C₂₀H₂₃N₃O₂
Molecular Weight:337.422
Hs Code.:

7-methyl-1-phenethyl-2,3-dihydro-1<i>H</i>-[1,8]naphthyridin-4-one <i>O</i>-oxiranylmethyl-oxime

Synonyms:7-methyl-1-phenethyl-2,3-dihydro-1H-[1,8]naphthyridin-4-one O-oxiranylmethyl-oxime

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Chemical Property of 7-methyl-1-phenethyl-2,3-dihydro-1H-[1,8]naphthyridin-4-one O-oxiranylmethyl-oxime

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Technology Process of 7-methyl-1-phenethyl-2,3-dihydro-1H-[1,8]naphthyridin-4-one O-oxiranylmethyl-oxime

There total 6 articles about 7-methyl-1-phenethyl-2,3-dihydro-1H-[1,8]naphthyridin-4-one O-oxiranylmethyl-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 106-89-8,24969-06-0,13403-37-7
epichlorohydrin

: 309728-69-6
7-methyl-1-phenethyl-2,3-dihydro-1H-[1,8]naphthyridin-4-one oxime

: 309728-77-6
7-methyl-1-phenethyl-2,3-dihydro-1H-[1,8]naphthyridin-4-one O-oxiranylmethyl-oxime

Guidance literature:: 7-methyl-1-phenethyl-2,3-dihydro-1H-[1,8]naphthyridin-4-one oxime; With sodium methylate; In methanol; for 1h; Heating;

epichlorohydrin; In toluene; at 100 ℃; for 24h;
DOI:10.1016/S0223-5234(00)00173-2

Reference yield:

: 1824-81-3
2-Amino-6-methylpyridine

: 309728-77-6
7-methyl-1-phenethyl-2,3-dihydro-1H-[1,8]naphthyridin-4-one O-oxiranylmethyl-oxime

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaBH₄ / methanol / 48 h / 20 °C

2.1: acetic acid / 72 h / 100 °C

3.1: aq. NaOH / 1 h / Heating

4.1: polyphosphoric acid / 0.67 h / 120 °C

5.1: 52 percent / NH₂OH*HCl / ethanol; pyridine / 1.5 h / Heating

6.1: NaOMe / methanol / 1 h / Heating

6.2: 36 percent / toluene / 24 h / 100 °C

With sodium hydroxide; sodium tetrahydroborate; PPA; hydroxylamine hydrochloride; sodium methylate; In pyridine; methanol; ethanol; acetic acid; 1.1: Condensation / 2.1: Addition / 3.1: Hydrolysis / 4.1: cyclocondensation / 5.1: Condensation / 6.1: salt formation / 6.2: Substitution;
DOI:10.1016/S0223-5234(00)00173-2

Reference yield:

: 122-78-1
phenylacetaldehyde

: 309728-77-6
7-methyl-1-phenethyl-2,3-dihydro-1H-[1,8]naphthyridin-4-one O-oxiranylmethyl-oxime

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaBH₄ / methanol / 48 h / 20 °C

2.1: acetic acid / 72 h / 100 °C

3.1: aq. NaOH / 1 h / Heating

4.1: polyphosphoric acid / 0.67 h / 120 °C

5.1: 52 percent / NH₂OH*HCl / ethanol; pyridine / 1.5 h / Heating

6.1: NaOMe / methanol / 1 h / Heating

6.2: 36 percent / toluene / 24 h / 100 °C

With sodium hydroxide; sodium tetrahydroborate; PPA; hydroxylamine hydrochloride; sodium methylate; In pyridine; methanol; ethanol; acetic acid; 1.1: Condensation / 2.1: Addition / 3.1: Hydrolysis / 4.1: cyclocondensation / 5.1: Condensation / 6.1: salt formation / 6.2: Substitution;
DOI:10.1016/S0223-5234(00)00173-2