2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanenitrile

Base Information

Chemical Name:2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanenitrile
CAS No.:1263091-35-5
Molecular Formula:C₁₅H₁₃F₃N₂O₂
Molecular Weight:310.276
Hs Code.:

Synonyms:2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanenitrile

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Chemical Property of 2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanenitrile

Chemical Property:

Purity/Quality:

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Technology Process of 2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanenitrile

There total 11 articles about 2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189145-21-8
4-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-5-cyclopropylisoxazole

: 1263091-35-5
2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanenitrile

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1263093-10-2
2-(3-fluoro-2-methyl-4-(trifluoromethyl)phenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

: 1263091-35-5
2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanenitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / ISOPROPYLAMIDE / 0.08 h

1.2: 0.75 h / 140 °C

2.1: hydrogenchloride / water / 4 h / Reflux

3.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / tetrahydrofuran / 22 h / 0 - 20 °C

3.2: 20 °C

4.1: trifluoroacetic acid / Reflux

5.1: 16 h / 20 °C

6.1: hydroxylamine hydrochloride / ethanol / 0.08 h

6.2: 20 °C

7.1: triethylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; hydroxylamine hydrochloride; potassium tert-butylate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; water;

Reference yield:

: 115754-21-7
3-fluoro-4-(trifluoromethyl)benzoic acid

: 1263091-35-5
2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanenitrile

Guidance literature:: Multi-step reaction with 11 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C / Reflux

2.1: dichloromethane / 17.5 h / 5 - 25 °C

3.1: thionyl chloride / dichloromethane / 5 h / 20 °C

4.1: n-butyllithium / n-heptane; tetrahydrofuran / -70 - -62 °C / Inert atmosphere

4.2: -70 - 20 °C

5.1: potassium tert-butylate / ISOPROPYLAMIDE / 0.08 h

5.2: 0.75 h / 140 °C

6.1: hydrogenchloride / water / 4 h / Reflux

7.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / tetrahydrofuran / 22 h / 0 - 20 °C

7.2: 20 °C

8.1: trifluoroacetic acid / Reflux

9.1: 16 h / 20 °C

10.1: hydroxylamine hydrochloride / ethanol / 0.08 h

10.2: 20 °C

11.1: triethylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; n-butyllithium; thionyl chloride; oxalyl dichloride; hydroxylamine hydrochloride; potassium tert-butylate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;