4-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-5-cyclopropylisoxazole

Base Information

Chemical Name:4-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-5-cyclopropylisoxazole
CAS No.:1189145-21-8
Molecular Formula:C₁₅H₁₃F₃N₂O₂
Molecular Weight:310.276
Hs Code.:

Synonyms:4-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-5-cyclopropylisoxazole

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Chemical Property of 4-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-5-cyclopropylisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 4-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-5-cyclopropylisoxazole

There total 10 articles about 4-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-5-cyclopropylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263093-15-7
1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-2-[(dimethylamino)methylene]propane-1,3-dione

: 1189145-21-8
4-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-5-cyclopropylisoxazole

Guidance literature:: 1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-2-[(dimethylamino)methylene]propane-1,3-dione; With hydroxylamine hydrochloride; In ethanol; for 0.0833333h;

With sodium acetate; In ethanol; at 20 ℃;

Reference yield:

: 1263093-09-9
2-[3-fluoro-4-(trifluoromethyl)phenyl]-4,4-dimethyl-5H-oxazole

: 1189145-21-8
4-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-5-cyclopropylisoxazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / n-heptane; tetrahydrofuran / -70 - -62 °C / Inert atmosphere

1.2: -70 - 20 °C

2.1: potassium tert-butylate / ISOPROPYLAMIDE / 0.08 h

2.2: 0.75 h / 140 °C

3.1: hydrogenchloride / water / 4 h / Reflux

4.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / tetrahydrofuran / 22 h / 0 - 20 °C

4.2: 20 °C

5.1: trifluoroacetic acid / Reflux

6.1: 16 h / 20 °C

7.1: hydroxylamine hydrochloride / ethanol / 0.08 h

7.2: 20 °C

With hydrogenchloride; n-butyllithium; hydroxylamine hydrochloride; potassium tert-butylate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In tetrahydrofuran; ethanol; n-heptane; ISOPROPYLAMIDE; water;

Reference yield:

: 216144-68-2
3-fluoro-4-(trifluoromethyl)benzoyl chloride

: 1189145-21-8
4-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-5-cyclopropylisoxazole

Guidance literature:: Multi-step reaction with 9 steps

1.1: dichloromethane / 17.5 h / 5 - 25 °C

2.1: thionyl chloride / dichloromethane / 5 h / 20 °C

3.1: n-butyllithium / n-heptane; tetrahydrofuran / -70 - -62 °C / Inert atmosphere

3.2: -70 - 20 °C

4.1: potassium tert-butylate / ISOPROPYLAMIDE / 0.08 h

4.2: 0.75 h / 140 °C

5.1: hydrogenchloride / water / 4 h / Reflux

6.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / tetrahydrofuran / 22 h / 0 - 20 °C

6.2: 20 °C

7.1: trifluoroacetic acid / Reflux

8.1: 16 h / 20 °C

9.1: hydroxylamine hydrochloride / ethanol / 0.08 h

9.2: 20 °C

With hydrogenchloride; n-butyllithium; thionyl chloride; hydroxylamine hydrochloride; potassium tert-butylate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; ISOPROPYLAMIDE; water;