6-(3-allyl-5-fluoro-2-phenyl-1H-indol-1-yl)-5-amino-4,5-dihydro-1,2,4-triazine-3(2H)-thione

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Chemical Name:6-(3-allyl-5-fluoro-2-phenyl-1H-indol-1-yl)-5-amino-4,5-dihydro-1,2,4-triazine-3(2H)-thione
CAS No.:1613132-91-4
Molecular Formula:C₂₀H₁₈FN₅S
Molecular Weight:379.461
Hs Code.:

Synonyms:6-(3-allyl-5-fluoro-2-phenyl-1H-indol-1-yl)-5-amino-4,5-dihydro-1,2,4-triazine-3(2H)-thione

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Chemical Property of 6-(3-allyl-5-fluoro-2-phenyl-1H-indol-1-yl)-5-amino-4,5-dihydro-1,2,4-triazine-3(2H)-thione

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Technology Process of 6-(3-allyl-5-fluoro-2-phenyl-1H-indol-1-yl)-5-amino-4,5-dihydro-1,2,4-triazine-3(2H)-thione

There total 6 articles about 6-(3-allyl-5-fluoro-2-phenyl-1H-indol-1-yl)-5-amino-4,5-dihydro-1,2,4-triazine-3(2H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1613132-85-6
C₁₇H₁₄FN₅S

: 106-95-6
allyl bromide

: 1613132-91-4
6-(3-allyl-5-fluoro-2-phenyl-1H-indol-1-yl)-5-amino-4,5-dihydro-1,2,4-triazine-3(2H)-thione

Guidance literature:: With zinc; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.ejmech.2014.04.043

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1613132-91-4
6-(3-allyl-5-fluoro-2-phenyl-1H-indol-1-yl)-5-amino-4,5-dihydro-1,2,4-triazine-3(2H)-thione

Guidance literature:: Multi-step reaction with 5 steps

1.1: neat (no solvent) / 3 h / 20 °C / Green chemistry

1.2: 255 / 0.02 h / Microwave irradiation; Green chemistry

2.1: potassium carbonate / toluene / Reflux

3.1: sodium hydroxide / ethanol / 8 h / Reflux

4.1: potassium permanganate; ammonia / 0.25 h / 0 °C

5.1: zinc / tetrahydrofuran / 20 °C

With potassium permanganate; ammonia; potassium carbonate; sodium hydroxide; zinc; In tetrahydrofuran; ethanol; toluene; 1.1: |Bischler-Moehlau Indole Synthesis / 1.2: |Bischler-Moehlau Indole Synthesis;
DOI:10.1016/j.ejmech.2014.04.043

Reference yield:

: 1613132-73-2
C₁₆H₁₁ClFNO

: 1613132-91-4
6-(3-allyl-5-fluoro-2-phenyl-1H-indol-1-yl)-5-amino-4,5-dihydro-1,2,4-triazine-3(2H)-thione

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol / 8 h / Reflux

2: potassium permanganate; ammonia / 0.25 h / 0 °C

3: zinc / tetrahydrofuran / 20 °C

With potassium permanganate; ammonia; sodium hydroxide; zinc; In tetrahydrofuran; ethanol;
DOI:10.1016/j.ejmech.2014.04.043