5'-methyl-2'-(biphenylmethyl)-3'-(phenylmethyl)spiro[cyclopentane-1,7'(8'H)-[3H]imidazo[2,1-b]purin]-4'(5'H)-one

Base Information

• Chemical Name: 5'-methyl-2'-(biphenylmethyl)-3'-(phenylmethyl)spiro[cyclopentane-1,7'(8'H)-[3H]imidazo[2,1-b]purin]-4'(5'H)-one
• CAS No.: 191982-37-3
• Molecular Formula: C₃₂H₃₁N₅O
• Molecular Weight: 501.631

Synonyms:5'-methyl-2'-(biphenylmethyl)-3'-(phenylmethyl)spiro[cyclopentane-1,7'(8'H)-[3H]imidazo[2,1-b]purin]-4'(5'H)-one

Chemical Property of 5'-methyl-2'-(biphenylmethyl)-3'-(phenylmethyl)spiro[cyclopentane-1,7'(8'H)-[3H]imidazo[2,1-b]purin]-4'(5'H)-one

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Technology Process of 5'-methyl-2'-(biphenylmethyl)-3'-(phenylmethyl)spiro[cyclopentane-1,7'(8'H)-[3H]imidazo[2,1-b]purin]-4'(5'H)-one

There total 6 articles about 5'-methyl-2'-(biphenylmethyl)-3'-(phenylmethyl)spiro[cyclopentane-1,7'(8'H)-[3H]imidazo[2,1-b]purin]-4'(5'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-Benzyl-8-biphenyl-4-ylmethyl-2-(1-hydroxymethyl-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one → 5'-methyl-2'-(biphenylmethyl)-3'-(phenylmethyl)spiro[cyclopentane-1,7'(8'H)-[3H]imidazo[2,1-b]purin]-4'(5'H)-one (191982-37-3)

Guidance literature:

With thionyl chloride; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1021/jm9608467

Reference yield:

(4-biphenylyl)acetic acid (5728-52-9) → 5'-methyl-2'-(biphenylmethyl)-3'-(phenylmethyl)spiro[cyclopentane-1,7'(8'H)-[3H]imidazo[2,1-b]purin]-4'(5'H)-one (191982-37-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1-<3-(diethylamino)propyl>-3-ethylcarbodiimide, 4-(N,N-dimethylamino)pyridine / dimethylformamide / Ambient temperature

2: POCl₃ / 7 h / Heating

3: diisopropylethylamine / various solvent(s) / 130 °C

4: SOCl₂ / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; thionyl chloride; N-ethyl-N'-(3-diethylaminopropyl)-carbodiimide; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm9608467

Reference yield:

(1-aminocyclopentyl)methanol (10316-79-7) → 5'-methyl-2'-(biphenylmethyl)-3'-(phenylmethyl)spiro[cyclopentane-1,7'(8'H)-[3H]imidazo[2,1-b]purin]-4'(5'H)-one (191982-37-3)

Guidance literature:

Multi-step reaction with 2 steps

1: diisopropylethylamine / various solvent(s) / 130 °C

2: SOCl₂ / CH₂Cl₂ / 3 h / Ambient temperature

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/jm9608467

upstream raw materials:

(4-biphenylyl)acetic acid

(1-aminocyclopentyl)methanol

6-amino-5-(benzylamino)-3-methylpyrimidine-2,4(1H,3H)-dione

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