(1R,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methylpropionic amide

Base Information

Chemical Name:(1R,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methylpropionic amide
CAS No.:121335-18-0
Molecular Formula:C₁₃H₁₇NO₄
Molecular Weight:251.282
Hs Code.:

Synonyms:(1R,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methylpropionic amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methylpropionic amide

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Technology Process of (1R,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methylpropionic amide

There total 2 articles about (1R,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methylpropionic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67376-70-9
N-((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-malonamic acid methyl ester

: 121335-18-0
(1R,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methylpropionic amide

Guidance literature:: With lithium hydroxide; In methanol; water; at 0 ℃; for 12h; Yield given;

Reference yield:

: 321-98-2,7009-81-6,90-83-5,6912-63-6
(1S,2R)-(+)-ephedrine

: 121335-18-0
(1R,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methylpropionic amide

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 120 h / Heating

2: LiOH / methanol; H₂O / 12 h / 0 °C

With lithium hydroxide; In methanol; water;

Reference yield: 84.0%

: 1609272-49-2
(((2S,4R,6S)-2-allyl-6-(iodomethyl)tetrahydro-2H-pyran-4-yl)oxy)(tert-butyl)-dimethylsilane

: 121335-18-0
(1R,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methylpropionic amide

: (R)-3-((2R,4R,6S)-6-allyl-4-((tert-butyldimethylsilyl)oxy)tetrahydro-2H-pyran-2-yl)-N-((1S,2S)-1-Hydroxy-1-phenylpropan-2-yl)-N,2-dimethylpropanamide

Guidance literature:: (1R,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methylpropionic amide; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2.58333h; Inert atmosphere;

(((2S,4R,6S)-2-allyl-6-(iodomethyl)tetrahydro-2H-pyran-4-yl)oxy)(tert-butyl)-dimethylsilane; In tetrahydrofuran; at 45 ℃; for 48h;
DOI:10.1002/anie.201400605