67376-70-9Relevant academic research and scientific papers
A SHORT EFFECTIVE PREPARATION OF CHIRAL N,3-DIMETHYL-5,7-DIOXO-2-PHENYLHEXAHYDRO-1,4-OXAZEPINES
Brown, Richard T.,Ford, Mark J.
, p. 1801 - 1806 (2007/10/02)
An improved two-stage procedure has been devised for the synthesis in 50percent yield of the title compounds from ephedrine or pseudoephedrine enantiomers and dimethyl malonate using cyanuric chloride/pyridine to lactonise the intermediate ε-hydroxyacids.
