(2S,5S,6S)-5-methyl-6-phenyl-5,6-dihydro-(2H)-pyran-2-carboxylic acid methyl ester

Base Information

• Chemical Name: (2S,5S,6S)-5-methyl-6-phenyl-5,6-dihydro-(2H)-pyran-2-carboxylic acid methyl ester
• CAS No.: 307972-91-4
• Molecular Formula: C₁₄H₁₆O₃
• Molecular Weight: 232.279

Synonyms:(2S,5S,6S)-5-methyl-6-phenyl-5,6-dihydro-(2H)-pyran-2-carboxylic acid methyl ester

Chemical Property of (2S,5S,6S)-5-methyl-6-phenyl-5,6-dihydro-(2H)-pyran-2-carboxylic acid methyl ester

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Technology Process of (2S,5S,6S)-5-methyl-6-phenyl-5,6-dihydro-(2H)-pyran-2-carboxylic acid methyl ester

There total 4 articles about (2S,5S,6S)-5-methyl-6-phenyl-5,6-dihydro-(2H)-pyran-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

benzaldehyde (100-52-7) + (E)-(2S,3S)-3-(Dimethyl-phenyl-silanyl)-2-hydroxy-hex-4-enoic acid methyl ester → (2S,5S,6S)-5-methyl-6-phenyl-5,6-dihydro-(2H)-pyran-2-carboxylic acid methyl ester (307972-91-4) + (2R,5S,6S)-5-methyl-6-phenyl-5,6-dihydro-(2H)-pyran-2-carboxylic acid methyl ester

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃;

DOI:10.1021/ja002087u

Reference yield: 87.0%

benzaldehyde (100-52-7) + methyl (2R,3S)-(E)-3-(dimethyl(phenyl)silyl)-2-(trimethylsilyloxy)-hex-4-enoate → (2S,5S,6R)-5-Methyl-6-phenyl-5,6-dihydro-2H-pyran-2-carboxylic acid methyl ester + (2S,5S,6S)-5-methyl-6-phenyl-5,6-dihydro-(2H)-pyran-2-carboxylic acid methyl ester (307972-91-4)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -20 ℃; for 3h;

DOI:10.1021/ja002087u

Reference yield: 85.0%

benzaldehyde (100-52-7) + methyl(2S,3S)-E-3-(dimethylphenylsilyl)-2-(trimethylsiloxy)-hex-4-enoate → (2S,5S,6S)-5-methyl-6-phenyl-5,6-dihydro-(2H)-pyran-2-carboxylic acid methyl ester (307972-91-4) + (2R,5S,6S)-5-methyl-6-phenyl-5,6-dihydro-(2H)-pyran-2-carboxylic acid methyl ester

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -20 ℃; for 3h;

DOI:10.1021/ja002087u

upstream raw materials:

benzaldehyde

Downstream raw materials:

[(2S,5S,6S)-5-methyl-6-phenyl-tetrahydro-2H-pyran-2-yl]methanol

(2S,3S,5S,6S)-3-Hydroxy-5-methyl-6-phenyl-tetrahydro-pyran-2-carboxylic acid methyl ester

methyl (2S,5S,6S)-5-methyl-6-phenyl-tetrahydro-2H-pyran-2-carboxylate

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