N-(2-bromophenethyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide

Base Information

• Chemical Name: N-(2-bromophenethyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide
• CAS No.: 1310552-78-3
• Molecular Formula: C₁₅H₁₇BrF₃NOSi
• Molecular Weight: 392.291
• Mol file: 1310552-78-3.mol

Synonyms:N-(2-bromophenethyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide

Chemical Property of N-(2-bromophenethyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-bromophenethyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide

There total 3 articles about N-(2-bromophenethyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

N-(2-bromophenethyl)-2,2,2-trifluoroacetamide (1057246-44-2) + (2-(trimethylsilyl)ethynyl)(phenyl)iodonium trifluoromethanesulfonate → N-(2-bromophenethyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide (1310552-78-3)

Guidance literature:

With potassium hexamethylsilazane; In toluene; at 20 - 80 ℃; for 2.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.03.118

Reference yield:

2-(2-bromophenyl)ethanamine (65185-58-2) → N-(2-bromophenethyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide (1310552-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: potassium hexamethylsilazane / toluene / 2.5 h / 20 - 80 °C / Inert atmosphere

With pyridine; potassium hexamethylsilazane; In dichloromethane; toluene;

DOI:10.1016/j.tetlet.2011.03.118

Reference yield:

Bis(trimethylsilyl)ethyne (14630-40-1) → N-(2-bromophenethyl)-2,2,2-trifluoro-N-(2-(trimethylsilyl)ethynyl) acetamide (1310552-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / 1 h / Inert atmosphere

1.2: 0.33 h / 0 °C / Inert atmosphere

1.3: 0.67 h / Inert atmosphere

2.1: potassium hexamethylsilazane / toluene / 2.5 h / 20 - 80 °C / Inert atmosphere

With water; potassium hexamethylsilazane; sodium hydroxide; In toluene;

DOI:10.1016/j.tetlet.2011.03.118

upstream raw materials:

N-(2-bromophenethyl)-2,2,2-trifluoroacetamide

2-(2-bromophenyl)ethanamine

Bis(trimethylsilyl)ethyne