(2R,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-8-[(4-methoxybenzyl)oxy]-3-(methoxymethoxy)-2-methyl-1-octanol

Base Information

Chemical Name:(2R,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-8-[(4-methoxybenzyl)oxy]-3-(methoxymethoxy)-2-methyl-1-octanol
CAS No.:825612-55-3
Molecular Formula:C₂₅H₄₆O₆Si
Molecular Weight:470.722
Hs Code.:

Synonyms:(2R,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-8-[(4-methoxybenzyl)oxy]-3-(methoxymethoxy)-2-methyl-1-octanol

Suppliers and Price of (2R,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-8-[(4-methoxybenzyl)oxy]-3-(methoxymethoxy)-2-methyl-1-octanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-8-[(4-methoxybenzyl)oxy]-3-(methoxymethoxy)-2-methyl-1-octanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-8-[(4-methoxybenzyl)oxy]-3-(methoxymethoxy)-2-methyl-1-octanol

There total 6 articles about (2R,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-8-[(4-methoxybenzyl)oxy]-3-(methoxymethoxy)-2-methyl-1-octanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 825612-54-2
(4S)-4-benzyl-3-[(2S,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-8-[(4-methoxybenzyl)oxy]-3-(methoxymethoxy)-2-methyloctanoyl]-1,3-oxazolidin-2-one

: 825612-55-3
(2R,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-8-[(4-methoxybenzyl)oxy]-3-(methoxymethoxy)-2-methyl-1-octanol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; at 0 - 23 ℃; for 12h;
DOI:10.1002/chem.200400617

Reference yield:

: ethyl (3RS)-3-hydroxy-6-[(4-methoxybenzyl)oxy]hexanoate

: 825612-55-3
(2R,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-8-[(4-methoxybenzyl)oxy]-3-(methoxymethoxy)-2-methyl-1-octanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0 - 23 °C

2.1: 83 percent / DIBAL / CH₂Cl₂ / 2 h / -78 °C

3.1: N,N,N',N'-tetramethyl-1,2-ethanediamine; TMEDA / TiCl₄ / CH₂Cl₂ / 0.33 h / 0 °C

3.2: 78 percent / CH₂Cl₂ / 1 h / 0 °C

4.1: 86 percent / N,N-diisopropylethylamine; Bu₄NI / CH₂Cl₂ / 12 h / 0 - 23 °C

5.1: 80 percent / aq. NaBH₄ / tetrahydrofuran / 12 h / 0 - 23 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; titanium tetrachloride; In tetrahydrofuran; dichloromethane;
DOI:10.1002/chem.200400617

Reference yield:

: 825612-52-0
(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-6-[(4-methoxybenzyl)oxy]-hexanal

: 825612-55-3
(2R,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-8-[(4-methoxybenzyl)oxy]-3-(methoxymethoxy)-2-methyl-1-octanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N,N',N'-tetramethyl-1,2-ethanediamine; TMEDA / TiCl₄ / CH₂Cl₂ / 0.33 h / 0 °C

1.2: 78 percent / CH₂Cl₂ / 1 h / 0 °C

2.1: 86 percent / N,N-diisopropylethylamine; Bu₄NI / CH₂Cl₂ / 12 h / 0 - 23 °C

3.1: 80 percent / aq. NaBH₄ / tetrahydrofuran / 12 h / 0 - 23 °C

With sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; titanium tetrachloride; In tetrahydrofuran; dichloromethane;
DOI:10.1002/chem.200400617