1-(1-(4-methoxybenzyl)-2-oxo-3-(phenylamino)-1,2-dihydroquinolin-6-yl)urea

Base Information

Chemical Name:1-(1-(4-methoxybenzyl)-2-oxo-3-(phenylamino)-1,2-dihydroquinolin-6-yl)urea
CAS No.:1616393-12-4
Molecular Formula:C₂₄H₂₂N₄O₃
Molecular Weight:414.464
Hs Code.:

Synonyms:1-(1-(4-methoxybenzyl)-2-oxo-3-(phenylamino)-1,2-dihydroquinolin-6-yl)urea

Suppliers and Price of 1-(1-(4-methoxybenzyl)-2-oxo-3-(phenylamino)-1,2-dihydroquinolin-6-yl)urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-(1-(4-methoxybenzyl)-2-oxo-3-(phenylamino)-1,2-dihydroquinolin-6-yl)urea

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(1-(4-methoxybenzyl)-2-oxo-3-(phenylamino)-1,2-dihydroquinolin-6-yl)urea

There total 6 articles about 1-(1-(4-methoxybenzyl)-2-oxo-3-(phenylamino)-1,2-dihydroquinolin-6-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1616392-93-8
1-(3-bromo-1-(4-methoxybenzyl)-2-oxo-1,2-dihydroquinolin-6-yl)urea

: 62-53-3
aniline

: 1616393-12-4
1-(1-(4-methoxybenzyl)-2-oxo-3-(phenylamino)-1,2-dihydroquinolin-6-yl)urea

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; XPhos; In tert-butyl alcohol; Reflux; Inert atmosphere;
DOI:10.1016/j.bmc.2014.04.037

Reference yield:

: 64495-55-2
6-nitro-1,2-dihydroquinolin-2-one

: 1616393-12-4
1-(1-(4-methoxybenzyl)-2-oxo-3-(phenylamino)-1,2-dihydroquinolin-6-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: sodium bromate; hydrogen bromide / water / 4 h / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 - 50 °C

3: acetic acid; zinc / methanol / 0.5 h

4: water; acetic acid / 1 h / 20 °C

5: XPhos; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-butyl alcohol / Reflux; Inert atmosphere

With sodium bromate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrogen bromide; potassium carbonate; acetic acid; zinc; XPhos; In methanol; water; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol; 5: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2014.04.037

Reference yield:

: 296759-30-3
3-bromo-6-nitro-1,2-dihydroquinolin-2-one

: 1616393-12-4
1-(1-(4-methoxybenzyl)-2-oxo-3-(phenylamino)-1,2-dihydroquinolin-6-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 - 50 °C

2: acetic acid; zinc / methanol / 0.5 h

3: water; acetic acid / 1 h / 20 °C

4: XPhos; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-butyl alcohol / Reflux; Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; acetic acid; zinc; XPhos; In methanol; water; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol; 4: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2014.04.037