64495-55-2

Basic information

• Product Name: 2(1H)-Quinolinone, 6-nitro-
• Synonyms: 2(1H)-Quinolinone, 6-nitro-;6-Nitroquinolin-2(1H)-one;6-nitro-2(1H)-Quinolinone;2-Hydroxy-6-nitroquinoline;6-Nitrocarbostyril
• CAS NO: 64495-55-2
• Molecular Formula: C₉H₆N₂O₃
• Molecular Weight: 190.15554
• Mol File: 64495-55-2.mol
• Article Data: 26

Chemical Properties

• Melting Point: 280 °C
• Boiling Point: 441.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.419±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.35±0.70(Predicted)
• CAS DataBase Reference: 2(1H)-Quinolinone, 6-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinolinone, 6-nitro-(64495-55-2)
• EPA Substance Registry System: 2(1H)-Quinolinone, 6-nitro-(64495-55-2)

Safety Data

• Hazardous Substances Data: 64495-55-2(Hazardous Substances Data)

Usage

General Description

6-nitro-2(1H)-quinolinone is a chemical compound with the molecular formula C9H6N2O3. It is a yellow to orange crystalline solid that is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 2(1H)-Quinolinone, 6-nitro- is known for its strong biological activity and has been studied for its potential as a cytotoxic and antitumor agent. It can also be used as a dye intermediate and in the production of specialty chemicals. Additionally, 6-nitro-2(1H)-quinolinone has been investigated for its potential as a corrosion inhibitor in various industrial applications. Due to its versatile properties, this compound is of interest to researchers in the fields of medicinal chemistry, organic synthesis, and materials science.

Upstream product

• 613-50-3 6-nitroquinoline 
• 49609-07-6 2-amino-6-nitroquinoline 
• 29969-57-1 2-chloro-6-nitroquinoline 
• 612-62-4 2-Chloroquinoline 
• 13675-92-8 6-nitroquinoline-N-oxide 
• 59-31-4 2-hydroxyquinoline 
• 104-04-1 N-(4-Nitrophenyl)acetamide 
• 292638-85-8 acrylic acid methyl ester 
• 22246-16-8 6-nitro-3,4-dihydro-1H-quinolin-2-one 
• 59-31-4 2-quinolone 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 7664-93-9 sulfuric acid 
• 91538-60-2 N-(2-formyl-4-nitrophenyl)acetamide 
• 108-24-7 acetic anhydride 

Downstream Products

• 29969-57-1 2-chloro-6-nitroquinoline 
• 79207-68-4 6-amino-2(1H)-quinolinone 
• 1616393-01-1 3-bromo-1-(4-methoxybenzyl)-6-(3-methoxyphenyl)quinolin-2(1H)-one 
• 1627095-03-7 3,6-diethoxy-1-(4-methoxybenzyl)quinolin-2(1H)-one 
• 1616392-89-2 3-bromo-1-(4-methoxybenzyl)-6-nitroquinolin-2(1H)-one 
• 1616392-91-6 6-amino-3-bromo-1-(4-methoxybenzyl)quinolin-2(1H)-one 
• 1616392-93-8 1-(3-bromo-1-(4-methoxybenzyl)-2-oxo-1,2-dihydroquinolin-6-yl)urea 
• 1616392-95-0 N-(3-bromo-1-(4-methoxybenzyl)-2-oxo-1,2-dihydroquinolin-6-yl)acetamide 
• 1616392-97-2 3-bromo-6-iodo-1-(4-methoxybenzyl)quinolin-2(1H)-one 
• 1616392-99-4 3-bromo-6-cyano-1-(4-methoxybenzyl)quinolin-2(1H)-one 
• 1616393-03-3 3-bromo-6-ethoxy-1-(4-methoxybenzyl)quinolin-2(1H)-one 
• 1627095-04-8 3-ethoxy-6-iodo-1-(4-methoxybenzyl)quinolin-2(1H)-one 
• 1616393-08-8 N-(3-((1-(4-methoxybenzyl)-2-oxo-6-ureido-1,2-dihydroquinolin-3-yl)amino)phenyl)pyrrolidine-1-carboxamide 
• 1616393-10-2 N-(3-((1-(4-methoxybenzyl)-2-oxo-6-ureido-1,2-dihydroquinolin-3-yl)amino)-5-(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)phenyl)pyrrolidine-1-carboxamide 

Relevant articles and documents

Efficient visible light mediated synthesis of quinolin-2(1H)-ones from quinolineN-oxides

Quinolin-2(1H)-ones are one of the important classes of compounds due to their prevalence in natural products and in pharmacologically useful compounds. Here we present an unconventional and hitherto unknown photocatalytic approach to their synthesis from easily available quinoline-N-oxides. This reagent free highly atom economical photocatalytic method, with low catalyst loading, high yield and no undesirable by-product, provides an efficient greener alternative to all conventional synthesis reported to date. The robustness of the methodology has been successfully demonstrated with easy scaling up to the gram scale.

BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY

Bifunctional compounds, which find utility as modulators of B-cell lymphoma 6 protein (BCL6; target protein), are described herein. In particular, the bifunctional compounds of the present disclosure contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand that binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

SMALL MOLECULE INHIBITORS OF ACETYL COENZYME A SYNTHETASE SHORT CHAIN 2 (ACSS2)

The present invention relates to compounds of formula (I). The compounds may be used to modulate the acetyl coenzyme A synthetase short chain 2 (ACSS2) protein and may thereby treat, ameliorate or prevent a disease selected from cancer, bacterial infection, viral infection, parasitic infection, fungal infection, neurodegenerative disease, neurological disorder, cerebrovascular disease, cardiovascular disease, non- alcoholic fatty liver disease and obesity. Alternatively, or additionally, the compounds maybe used to promote healthy ageing.