(S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxypyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile

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Chemical Name:(S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxypyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
CAS No.:1609261-26-8
Molecular Formula:C₂₇H₃₁N₃O₆
Molecular Weight:493.56
Hs Code.:

Synonyms:(S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxypyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile

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Chemical Property of (S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxypyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile

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Technology Process of (S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxypyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile

There total 5 articles about (S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxypyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609261-17-7
(2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxy-pyrrolidine-2-carboxylic acid

: 204387-53-1
(2S)-pyrrolidine-2-carbonitrile

: 1609261-26-8
(S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxypyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile

Guidance literature:: (2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxy-pyrrolidine-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.0833333h;

(2S)-pyrrolidine-2-carbonitrile; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 83624-01-5
(2S,4R)-1-(tert-butoxycarbonyl)-4-methoxypyrrolidine-2-carboxylic acid

: 1609261-26-8
(S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxypyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane / 2 h / 0 - 20 °C

2.1: oxalyl dichloride / toluene / 1.5 h / 50 °C

2.2: 4.5 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h

3.2: 20 °C

With hydrogenchloride; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 884-35-5
methyl syringate

: 1609261-26-8
(S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxypyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / acetone / 0.5 h / 20 °C

1.2: 8 h / Reflux

2.1: sodium hydroxide; ethanol / 2 h / Reflux

3.1: oxalyl dichloride / toluene / 1.5 h / 50 °C

3.2: 4.5 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h

4.2: 20 °C

With oxalyl dichloride; ethanol; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; sodium hydroxide; In dichloromethane; acetone; toluene;